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4 Best Ketamine Therapy Clinics in Oklahoma City, Oklahoma

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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Oklahoma City, OK

Ketamine Therapy clinics in Oklahoma City

Oklahoma City has multiple clinics offering ketamine therapy, a fast growing segment for treatment resistant depression, PTSD, chronic pain, and anxiety. Oklahoma requires DEA registration for ketamine prescribing; the state has a small but growing ketamine clinic footprint. Most Oklahoma City clinics deliver IV ketamine infusions in a monitored clinical setting, typically across a 6 session induction protocol, followed by maintenance infusions. Spravato (esketamine), the FDA approved nasal spray for treatment resistant depression, is available in Oklahoma City only at REMS certified clinics and is often covered by insurance when medical necessity is documented. Compounded ketamine lozenges and troches are also prescribed in Oklahoma City, sometimes through telehealth platforms like Mindbloom, Joyous, and Innerwell, subject to Ryan Haight Act and DEA special registration considerations. Local pricing in Oklahoma City sits in the affordable range: single IV infusions run 400 to 700 dollars, a full 6 session protocol lands at 2,400 to 4,200, and Spravato copays depend on insurance coverage. A reputable Oklahoma City ketamine clinic will pair pharmacology with integration support, monitor vitals during infusion, and have a clear crisis and follow up plan.

4 Clinics

MD on staff

Oklahoma Pain Center

Oklahoma City, OK

Oklahoma Pain Center, a regenerative-medicine practice in Oklahoma City, specializes in stem-cell therapy, platelet-rich plasma injections, and ketamine infusion therapy for chronic musculoskeletal a…

  • PRP Therapy
  • Ketamine Therapy
  • Arthritis Treatment
  • Stem Cell Therapy

Rejuvenate Health & Wellness Lounge

Oklahoma City, OK

Rejuvenate Health & Wellness Lounge, an IV therapy clinic in Oklahoma City, offers a comprehensive array of regenerative and supportive-medicine treatments. The practice features IV nutrient therapy,…

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Shockwave Therapy
 MD on staff

LIT Clinic Psychiatry & Performance with Dr. Benjamin

Oklahoma City, OK

LIT Clinic Psychiatry & Performance in Oklahoma City provides ketamine-assisted psychotherapy alongside integrative psychiatry and performance coaching for adults. The clinic combines ketamine therap…

  • Ketamine Therapy
  • Peptide Therapy
 MD on staff

Integrative Psychiatry of Oklahoma

Oklahoma City, OK

Integrative Psychiatry of Oklahoma, in Oklahoma City, offers ketamine therapy as a clinical protocol for treatment-resistant depression, anxiety, and related psychiatric presentations. The practice e…

  • Vitamin IV Therapy
  • Ketamine Therapy
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Regulatory context

A note on Oklahoma's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • HB 2107 / Psilocybin Research (2023)
    Authorized and funded psilocybin research for PTSD treatment; does not create therapeutic access.
  • Oklahoma Uniform Controlled Dangerous Substances Act
    Mirrors federal scheduling.

Oklahoma enforces federal scheduling. The Oklahoma State Board of Medical Licensure and Supervision oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Oklahoma PMP requires controlled substance reporting. Oklahoma Bureau of Narcotics and Dangerous Drugs requires a state controlled substance registration in addition to federal DEA.

Sources: dea.gov · okmedicalboard.org · pharmacy.ok.gov · obn.ok.gov

Ketamine Therapy in Oklahoma City, answered.

In Oklahoma City, a single IV ketamine infusion typically runs 400 to 700 dollars, with a full 6 session induction protocol at 2,400 to 4,200. Premium clinics on the higher end, more affordable providers on the lower end. Intramuscular ketamine often costs less, around 250 to 500 per session. Compounded ketamine lozenges via telehealth run 250 to 500 per month. Spravato (esketamine) is frequently covered by insurance for treatment resistant depression; out of pocket list price is roughly 600 to 900 per treatment session, with most patients paying a copay.

Ketamine is a Schedule III controlled substance and has been FDA approved as an anesthetic since 1970. Spravato (esketamine), a derivative nasal spray, is FDA approved for treatment resistant depression under a REMS program requiring in clinic administration and post dose monitoring. IV, intramuscular, and compounded oral ketamine for depression, PTSD, and chronic pain are used off label with Emerging to Strong evidence depending on indication. Off label prescribing is legal for DEA registered providers but must follow state and federal controlled substance rules.

Oklahoma City ketamine is delivered by MDs and DOs (typically psychiatrists, anesthesiologists, emergency medicine, or pain specialists) holding a DEA registration and Oklahoma controlled substance authority. Nurse practitioners and physician assistants may prescribe or administer depending on Oklahoma scope of practice and supervisory rules. Spravato requires a REMS certified clinic and certified prescriber. Verify the provider's DEA registration, board certification, and whether a monitoring clinician is present during infusions.

Yes, with caveats. Mindbloom, Joyous, Innerwell, and similar platforms prescribe compounded ketamine lozenges to Oklahoma residents through telehealth, subject to the Ryan Haight Act and DEA special registration rules currently in effect. These programs pair at home dosing with virtual integration support and cost roughly 250 to 500 per month. In clinic IV and intramuscular ketamine remain the standard for treatment resistant depression and PTSD and cannot be delivered via telehealth. Spravato always requires in clinic REMS administration.

Verify DEA registration on the DEA Office of Diversion Control registrant lookup and Oklahoma medical board license status. Confirm board certification in psychiatry, anesthesiology, emergency medicine, or pain medicine. Ask about the monitoring protocol during infusion (vitals, continuous clinician presence), integration therapy options, and the clinic's crisis and safety plan. Check whether the clinic is Spravato REMS certified if that is your treatment path. Be cautious of providers who skip screening, push large prepaid packages, or offer take home IV ketamine.

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