ASCVD Risk Calculator: 10-Year Pooled Cohort Equations
- Calculator
- About 4 min
- Goff 2014 Pooled Cohort Equations
- Runs in your browser, nothing is sent
- Medical review: Medical review pending
What this calculator works out
ASCVD stands for atherosclerotic cardiovascular disease: heart attack, death from coronary disease, and stroke. The Pooled Cohort Equations estimate the chance of a first such event over the next ten years from nine routine facts, and US cholesterol guidelines used that estimate to decide when a statin discussion was warranted until the 2026 guideline moved to the newer PREVENT equations.
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Ten-year risk percent
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Guideline risk category
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The equation itself
How this compares with a typical online quiz
| Feature | Typical free quiz | Regenerated.com |
|---|---|---|
| Equation named and coefficients shown | Sometimes | Goff 2014, Appendix 7, Table A |
| Validated age range enforced | Rarely | Yes, 40 to 79; outside it the calculator stops |
| Guideline thresholds cited | Sometimes | 2018 ACC/AHA cholesterol guideline bands |
| Known overestimation stated | No | Yes, with the MESA calibration study |
| Newer PREVENT model explained | Rarely | Yes, in the section below |
| mg/dL and mmol/L handled | Sometimes | Yes, conversion in every field |
| Answers sent to a server | Often | Never; scored in your browser, counts-only events |
What the 2018 guideline did with the number
The 2018 ACC/AHA cholesterol guideline (Grundy and colleagues, 2019), the thresholds that accompanied this equation and that the 2026 guideline has since superseded, used the ten-year risk as the entry point for a clinician-patient risk discussion in adults aged 40 to 75 with LDL cholesterol between 70 and 189 mg/dL and no diabetes or existing cardiovascular disease. At 20 percent and above, a high-intensity statin to lower LDL by at least 50 percent is the guideline's recommendation. Between 7.5 and 20 percent, a moderate-intensity statin is reasonable if the discussion favors it, and risk-enhancing factors push toward treatment. Between 5 and 7.5 percent, a statin may be considered when risk enhancers are present. Under 5 percent, the emphasis is on lifestyle.
Two groups bypass the calculator entirely under those 2018 rules: anyone with LDL cholesterol of 190 mg/dL or more, and adults aged 40 to 75 with diabetes, for whom the guideline advises a statin regardless of the risk score. Risk-enhancing factors the guideline lists include a family history of premature ASCVD (a male relative before 55 or a female relative before 65), persistently elevated LDL of 160 mg/dL or more, metabolic syndrome, chronic kidney disease, chronic inflammatory conditions such as psoriasis, rheumatoid arthritis or HIV, premature menopause or a history of preeclampsia, South Asian ancestry, persistent triglycerides of 175 mg/dL or more, and, where measured, hs-CRP of 2.0 mg/L or more, lipoprotein(a) of 50 mg/dL or more, apolipoprotein B of 130 mg/dL or more, or an ankle-brachial index under 0.9.
Coronary artery calcium: the tie-breaker
When the risk falls in the intermediate band, or in the borderline band with risk enhancers, and the decision is still uncertain, the guideline supports a coronary artery calcium (CAC) scan: a low-dose CT without contrast that scores calcified plaque in the coronary arteries. A score of zero in a non-smoker without diabetes or a strong family history lets a clinician reasonably hold off a statin and repeat the scan in five to ten years. A score of 1 to 99 favors a statin, particularly after age 55. A score of 100 or more, or at the 75th percentile or above for age and sex, indicates a statin at any risk level.
The scan often costs around 100 to 200 dollars out of pocket in the United States, though it varies by center, and involves a small radiation dose. It measures what has already happened in the arteries rather than predicting it, which is why it reclassifies so many people whose equation result sits near a threshold.
PREVENT and the 2026 guideline: what this page computes, and what your clinician will use
In November 2023 the American Heart Association published the PREVENT equations (Khan and colleagues, 2024), derived from more than six million adults in contemporary US cohorts. PREVENT covers ages 30 to 79, drops race as an input, adds kidney function (eGFR) and body mass index, and can take HbA1c, urine albumin and a social deprivation index as optional inputs. It predicts total cardiovascular disease, including heart failure, over ten and thirty years, and it produces lower risk estimates than the Pooled Cohort Equations for most people, because the older equations were built on cohorts from the 1960s to 1990s and overestimate risk in today's population.
The 2026 ACC/AHA multisociety dyslipidemia guideline (Blumenthal and colleagues, published online March 13, 2026) replaced the Pooled Cohort Equations with PREVENT-ASCVD for adults aged 30 to 79, and replaced the 2018 categories with lower cut-offs: low under 3 percent, borderline 3 to under 5, intermediate 5 to under 10, and high 10 percent and above. This page still computes the 2013 equations for two reasons: they are the published model implemented here, and they are the number almost every reader was given before 2026, so they are the figure in older letters, apps and clinic notes. Read the result as exactly that, a 2013 estimate against the thresholds of its own era. A clinician using PREVENT will usually quote a lower percentage read against lower lines, which is not a contradiction. The pair of numbers worth asking for by name at your next appointment: what is my ten-year PREVENT-ASCVD risk, and which category does it fall into.
Methodology and sources
The calculator implements the race- and sex-specific Pooled Cohort Equations published in the 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk (Goff and colleagues, 2014), Appendix 7, Table A. The equations were derived from five NHLBI cohorts (Framingham original and offspring, ARIC, CARDIA and CHS) in non-Hispanic White and African American adults aged 40 to 79 without prior cardiovascular disease, and they predict the ten-year risk of a first hard ASCVD event. The guideline specifies that people of other races use the White coefficients, which is why the first race option here is labeled White or other. The equations are valid for ages 40 to 79 and the calculator refuses other ages; the ACC/AHA risk estimator accepts total cholesterol 130 to 320 mg/dL, HDL 20 to 100 mg/dL and systolic pressure 90 to 200 mmHg, and values outside those ranges are extrapolations.
For each group the natural logarithms of age, total cholesterol, HDL cholesterol and systolic blood pressure (with separate coefficients for treated and untreated pressure), a smoking flag, a diabetes flag and the listed interaction terms are multiplied by the published coefficients and summed. The sum minus the cohort mean is exponentiated, and ten-year risk equals 1 minus the group's baseline survival raised to that power. Worked example from the guideline: a 55-year-old White man with total cholesterol 213 mg/dL, HDL 50 mg/dL, untreated systolic pressure 120 mmHg, non-smoker, no diabetes, scores a sum of about 60.70 (the guideline's table prints 60.69) against a mean of 61.18 and a baseline survival of 0.9144, giving a ten-year risk of about 5.4 percent (the guideline's table prints 5.3 from unrounded coefficients). The same profile gives about 2.1 percent for a White woman, 6.1 for a Black man and 3.0 for a Black woman.
The bands use the categories of the 2018 ACC/AHA cholesterol guideline (Grundy and colleagues, 2019), the thresholds that accompanied this equation and that the 2026 ACC/AHA dyslipidemia guideline superseded: low under 5 percent, borderline 5 to under 7.5, intermediate 7.5 to under 20, high 20 and above. The 2026 guideline reads PREVENT risk against 3, 5 and 10 percent instead, so a clinician working from it will quote a different number against different lines. Two limits matter when reading the result. First, in the Multi-Ethnic Study of Atherosclerosis the equations overestimated observed events by 86 percent in men and 67 percent in women in a cohort aged 50 to 74 without diabetes (DeFilippis and colleagues, 2015), so the true risk for a modern, lower-smoking population is often somewhat lower than the number shown. Second, the equations do not see LDL cholesterol, lipoprotein(a), family history, kidney function or inflammation, which is why the guideline added risk enhancers and calcium scoring to the decision rather than relying on the percentage alone.
Medical review: Medical review pending. Last updated .
References
- Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-S73. https://doi.org/10.1161/01.cir.0000437741.48606.98
- Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. Circulation. 2019;139(25):e1082-e1143. https://doi.org/10.1161/CIR.0000000000000625
- Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia. J Am Coll Cardiol. Published online March 13, 2026. https://doi.org/10.1016/j.jacc.2025.11.016
- DeFilippis AP, Young R, Carrubba CJ, et al. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med. 2015;162(4):266-275. https://doi.org/10.7326/M14-1281
- Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association's PREVENT equations. Circulation. 2024;149(6):430-449. https://doi.org/10.1161/CIRCULATIONAHA.123.067626