Sermorelin Dosage Calculator: Units Per Dose
- Calculator
- About 3 min
- Standard reconstitution arithmetic (Boyer, Math for Nurses)
- Runs in your browser, nothing is sent
- Medical review: Medical review pending
What this calculator works out
Sermorelin ships as a lyophilized powder and the prescription is written in micrograms, but the syringe is marked in units. Three numbers bridge that gap, and a mistake in any of them changes the dose that actually goes in.
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1
Concentration after mixing
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2
Volume and syringe units per dose
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3
Full doses in the vial
How this compares with a typical online quiz
| Feature | Typical free quiz | Regenerated.com |
|---|---|---|
| Dose comes from your prescription, never a chart | Often shows a dose | Yes, only the prescribed dose is entered |
| Units and milliliters both shown | Sometimes | Yes, with the concentration that produced them |
| Doses per vial | Rarely | Yes, rounded down to full doses |
| Regulatory status stated | No | Yes, the Geref history and the 503A basis, with dates |
| Sells or links to peptides | Often | Never |
| Answers sent to a server | Often | Never; scored in your browser, counts-only events |
From Geref to the compounded vial in your refrigerator
Sermorelin is a synthetic copy of the first 29 amino acids of growth hormone-releasing hormone, the part of the natural hormone that tells the pituitary to release a pulse of growth hormone. The FDA approved it as Geref Diagnostic in 1990, for testing pituitary growth hormone release, and as Geref in 1997 for treating children whose growth had stalled because of growth hormone deficiency. EMD Serono discontinued both in 2008 for manufacturing and commercial reasons, not because of a safety finding, and the approvals were withdrawn in 2009, so there is no branded sermorelin on the US market today.
What clinics prescribe now is compounded sermorelin acetate, prepared by a licensed 503A pharmacy for a named patient. Sermorelin is not on the FDA's section 503A category lists at all: the category 1, 2 and 3 lists updated May 14, 2026, checked on October 8, 2026, do not name it, and it does not need to be. Section 503A lets a pharmacy compound from a bulk substance that is a component of an FDA-approved drug product, and sermorelin acetate was the active ingredient of Geref and Geref Diagnostic; the FDA's determination of March 4, 2013 recorded that those products were not withdrawn from sale for reasons of safety or effectiveness, which is why their withdrawal is not a safety finding against the molecule. What any one pharmacy may do does not follow from that alone, so ask the prescriber which pharmacy fills it and on what basis. That is still a different position from BPC-157 or TB-500, which were in 503A category 2 from September 2023, left category 2 in April 2026 only because the nominations were withdrawn by the nominators, and are neither on the 503A bulks list nor components of an FDA-approved drug product. Adult use for low growth hormone, body composition or recovery is off-label and clinician-directed; the published adult evidence is a handful of small trials in older men from the 1990s that showed higher growth hormone and IGF-1 levels, not large trials of long-term outcomes.
The doses that were studied, and why they are not yours
The approved Geref label dosed children by body weight: 30 mcg per kilogram once daily at bedtime, injected under the skin, and a single 1 mcg per kilogram intravenous dose for the diagnostic test. In the 1997 trial by Vittone and colleagues, eleven healthy men aged 64 to 76 took 2 mg of GHRH 1-29 as a single nightly injection for 6 weeks. These figures describe what was labeled and what was studied. They are not instructions, they were not written for your situation, and this calculator does not use them: the only dose it takes is the one your clinician prescribed.
Prescriptions for compounded sermorelin are usually written in micrograms. If yours is written in milligrams, multiply by 1,000 before entering it (0.3 mg is 300 mcg). If it is written in units, your pharmacy has already done this arithmetic for a specific vial and water volume, and you should confirm with them that your vial and water match before trusting any calculator.
Mixing, storing and the eleven-minute half-life
Compounded sermorelin arrives as a lyophilized powder, usually in 2, 5, 9 or 15 mg vials. The pharmacy specifies the diluent, almost always bacteriostatic water, and the volume. Add the water slowly down the side of the vial and swirl gently until the powder dissolves; shaking can damage peptide chains. Keep the mixed vial refrigerated, out of light, and ask the pharmacy for the beyond-use date, which is the date after which the vial is discarded whatever is left in it.
Sermorelin has a half-life of about 11 to 12 minutes, which is why it is dosed at bedtime: a short pulse timed to the body's own growth hormone release during the first hours of sleep. Rotating injection sites across the abdomen and thighs reduces lumps and bruising. Any change to the vial strength or the water volume changes the units per dose, so run the calculation again every time a new vial arrives.
Methodology and sources
The calculation is standard dimensional analysis for a reconstituted vial, as taught in nursing dosage textbooks such as Boyer's Math for Nurses, with the units conversion for a U-100 insulin syringe, where 100 units occupy 1 mL. It applies to any lyophilized peptide vial; nothing in it is specific to sermorelin, and it assumes the whole labeled amount dissolved in the water you added. The formula has three inputs and no hidden assumptions: vial milligrams, diluent milliliters and prescribed micrograms.
How this is calculated, in numbers: a 9 mg vial made up with 3 mL of bacteriostatic water holds 9 x 1,000 / 3 = 3,000 mcg/mL. A prescribed 300 mcg nightly dose is 300 / 3,000 = 0.1 mL, which is 0.1 x 100 = 10 units on a U-100 syringe, and the vial holds 9,000 / 300 = 30 full doses, a month of nights. Mix the same vial with 1.5 mL instead and the concentration doubles to 6,000 mcg/mL, so the identical dose becomes 0.05 mL, or 5 units, and the draw gets harder to read.
The result bands are about measurability, not about whether a dose is right. Standard insulin syringes are marked in 1 or 2 unit steps, and half-unit syringes exist; below about 5 units a single mark of error is a large share of the dose, and above 100 units the dose does not fit one syringe. A clinician or pharmacist can change the water volume to move the draw into a readable range without changing the dose.
Medical review: Medical review pending. Last updated .
References
- Boyer MJ. Math for Nurses: A Pocket Guide to Dosage Calculation and Drug Preparation. 9th ed. Philadelphia: Wolters Kluwer; 2016. ISBN 978-1-4963-0369-2.
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157. doi:10.2165/00063030-199912020-00007.
- Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997;46(1):89-96. doi:10.1016/s0026-0495(97)90174-8.
- Corpas E, Harman SM, Pineyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab. 1992;75(2):530-535. doi:10.1210/jcem.75.2.1379256.
- US Food and Drug Administration. Bulk drug substances nominated for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act, category list updated May 14, 2026, on which sermorelin does not appear; checked October 8, 2026. https://www.fda.gov/media/94155/download. And Determination that GEREF (sermorelin acetate) injection was not withdrawn from sale for reasons of safety or effectiveness. 78 Fed Reg 14095 (March 4, 2013). https://www.federalregister.gov/documents/2013/03/04/2013-04827/determination-that-geref-sermorelin-acetate-injection-05-milligrams-basevial-and-10-milligrams