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Colon Hydrotherapy: Benefits, Risks, and What Actually Happens During a Session

Colon hydrotherapy flushes the large intestine with 15 to 20 gallons of warm, filtered water over a 30 to 45 minute session. It may briefly ease bloating and constipation, but a 2009 systematic review found no rigorous evidence of benefit for general health.

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Colon Hydrotherapy

Colon hydrotherapy, also called colonic irrigation or a colonic, flushes the large intestine with warm, filtered water through a small rectal tube, typically 15 to 20 gallons over a 30 to 45 minute session. Its reported benefits are short term relief of bloating and constipation, its common side effects are cramping, nausea and loose stools, and a 2009 systematic review by Acosta and Cash in the American Journal of Gastroenterology found no rigorous controlled trials supporting it for general health [10].

A colonic is different from an enema and from colonoscopy prep, its serious risks are rare but real, and professional contraindication lists rule it out for people with conditions such as active inflammatory bowel disease, recent bowel surgery and severe anemia. For anyone who goes ahead after screening, the directory of colon hydrotherapy clinics lets you compare practitioners by location.

Key Takeaways

  • The FDA classifies colonic irrigation systems as Class II devices only when colon cleansing is medically indicated, such as before radiological or endoscopic exams; routine cleansing for general well being falls under Class III, which requires premarket approval (21 CFR 876.5220).
  • Acosta and Cash (2009) reviewed the traditional and complementary medicine literature and concluded that colon cleansing for general health is not supported by published evidence, while multiple case reports and case series describe adverse effects (PubMed 19724266).
  • The best supported uses of irrigation are medical ones: bowel preparation before a procedure and transanal irrigation for constipation and fecal incontinence, studied by Christensen and colleagues (2009) [11].
  • Bowel cleansing lowers the gut microbial load sharply but temporarily: Jalanka and colleagues (2015) measured a 31-fold drop after an oral bowel prep in 23 healthy adults, with bacterial levels essentially restored within 14 days (PubMed 25527456).
  • Bowel perforation, electrolyte imbalance and infection from poorly cleaned equipment are the serious risks reported in case reports, including Handley and colleagues (2004) in the Medical Journal of Australia [13].
  • Practitioner contraindication lists exclude people with active Crohn’s disease or ulcerative colitis, recent bowel surgery, colorectal cancer, severe heart or kidney disease, severe anemia and pregnancy.

At a Glance

  • Colon hydrotherapy involves gently flushing the large intestine with warm, filtered water through a small rectal tube, in repeated fill and release cycles
  • It differs from a standard enema in volume, depth of cleansing, and professional supervision
  • Proposed benefits include reduced bloating, improved digestion, increased energy, and support for detoxification pathways; only bloating and constipation relief have small studies behind them
  • Clinical evidence is limited; most support comes from case reports, small pilot studies and practitioner observations rather than large randomized trials
  • Risks include electrolyte imbalance, bowel perforation (rare), and infection if equipment is not properly sterilized
  • People with inflammatory bowel disease, recent abdominal surgery, severe kidney disease or severe anemia should avoid the procedure

What Is Colon Hydrotherapy?

Colon hydrotherapy (also called colonic irrigation, colonic lavage, a high colonic or simply “a colonic”) is a procedure that flushes the large intestine with warm, purified water. A trained therapist inserts a small, disposable speculum into the rectum, connected to a machine that controls water temperature, pressure, and flow. Water enters the colon, softens and loosens accumulated waste, and then exits through a separate channel in the tubing, carrying fecal matter, gas, and mucus with it [1].

A typical session lasts 30 to 45 minutes and uses approximately 15 to 20 gallons of water, introduced and released in repeated cycles. The therapist may gently massage the abdomen to help dislodge material in specific areas of the colon. The entire process is contained within a closed system, so there is no odor and no mess.

Two equipment designs are in use. Closed systems, the type described above, are run by the therapist, who controls inflow and outflow through a speculum. Open systems use gravity: the client lies over a basin, inserts a thin, pencil-sized tube, and releases water around it, with the therapist nearby rather than at the controls.

The practice has roots stretching back thousands of years. Ancient Egyptian medical texts reference intestinal cleansing, and the procedure gained popularity in European health spas in the 19th century. It rested on the theory of “autointoxication,” the idea that retained stool poisons the body, which mainstream medicine set aside in the early 20th century. Modern colon hydrotherapy uses FDA-registered equipment with disposable components, temperature sensors, and pressure regulators to keep the experience controlled [2]. FDA registration means the device maker is listed with the agency; it is not an FDA approval of colonics for wellness.

The colon hydrotherapy treatment guide covers the procedure in more depth, including how it fits alongside gut health care such as diet changes, fiber, probiotics and testing for small intestinal bacterial overgrowth (SIBO).

Colon Hydrotherapy Benefits and Side Effects: Summary Table

Colon hydrotherapy is reported to relieve bloating and constipation in the short term, and its side effects range from common cramping to rare bowel perforation. The table pairs each claim with what the research in the Sources section shows, so you can weigh the benefits and side effects side by side.

Claim or effectWhat the evidence showsStrength of evidence
Relief of bloating and abdominal distensionA small pilot study of a colonic irrigation system in irritable bowel syndrome (Hsu and colleagues, 2016) reported symptom relief [1].Low: small, uncontrolled studies
Relief of constipation and defecation disordersStudies of medically supervised transanal irrigation report benefit for some patients (Koch and colleagues, 2008; Christensen and colleagues, 2009) [4] [11].Moderate for medical irrigation, low for spa colonics
DetoxificationNo controlled trials show colonics remove toxins; the liver and kidneys clear most metabolic waste (Acosta and Cash, 2009) [10].Not supported
Energy, mental clarity, clearer skinBased on client reports and the gut-brain and gut-skin axis research, not on colonic trials [8] [9].Not tested directly
Cramping, nausea, loose stools, fatigueCommon and usually short lived, reported in reviews of colon cleansing (Mishori and colleagues, 2011) [14].Well documented
Electrolyte imbalance and dehydrationReported in case reports, more likely with repeated sessions, diuretics or kidney disease [12].Case reports
Bowel perforationRare; case reports link it to existing bowel disease, nonstandard equipment or untrained operators [13].Case reports
Infection from equipmentPreventable with single-use disposable kits; an outbreak of amebiasis was traced to a colonic irrigation machine at a Colorado clinic (Istre and colleagues, 1982).Case reports

Colon Hydrotherapy vs. Enema: What’s the Difference?

People often conflate colonics with enemas, but they are quite different in scope.

An enema introduces a small volume of liquid (typically 1 to 2 quarts) into the lower portion of the colon. You can do it at home with an over-the-counter kit, and the liquid is held briefly before being expelled into the toilet. Enemas primarily reach the rectum and sigmoid colon.

Colon hydrotherapy, by contrast, uses significantly more water and involves multiple fill-and-release cycles over 30 to 45 minutes. The water can reach further into the colon, potentially cleansing the ascending, transverse, and descending segments. It requires professional equipment and a trained therapist.

Think of it this way: an enema is like rinsing a few dishes in the sink, while a colonic is more like running the dishwasher through a full cycle. Both involve water and cleaning, but the depth and thoroughness differ substantially.

Two medical procedures are also easy to confuse with a colonic. Transanal irrigation is a prescribed bowel management method that patients with neurogenic bowel or fecal incontinence use at home under medical guidance [11]. Oral bowel preparation, such as a polyethylene glycol solution taken before a colonoscopy, cleans the whole colon from above and is ordered by a gastroenterologist.

MethodHow it worksWho performs itMain use
Enema1 to 2 quarts of liquid, held briefly, reaches the rectum and sigmoid colonSelf at home, or nurseOccasional constipation, some procedures
Colon hydrotherapy15 to 20 gallons of warm water in repeated cycles over 30 to 45 minutesColon hydrotherapistWellness and comfort claims, sometimes ordered as a bowel prep
Transanal irrigationWater through a rectal catheter on a regular schedulePatient, trained by a clinicianChronic constipation, fecal incontinence, neurogenic bowel
Oral bowel preparationDrinkable laxative solution cleans the whole colonPrescribed by a physicianColonoscopy and bowel surgery

What Happens During a Session: Step by Step

Before You Arrive

Most practitioners recommend eating lightly for 24 hours before your appointment. Heavy, processed meals and large amounts of dairy are best avoided. Drinking plenty of water in the days leading up to your session helps soften stool and makes the procedure more comfortable and productive. You’ll be asked to refrain from eating for about two hours before your appointment.

The Intake

Your therapist will review your health history, ask about medications, digestive symptoms, and any contraindications. This is when you should mention any conditions like diverticulitis, Crohn’s disease, ulcerative colitis, recent surgery, anemia, heart or kidney disease, or pregnancy. A good practitioner will refuse to proceed if they identify risk factors.

Getting Started

You’ll change into a gown in a private room. The therapist will explain the equipment and the process. You lie on your left side or on your back on a treatment table. The therapist inserts a small, lubricated, disposable speculum (about the diameter of a pencil) into the rectum. This takes a few seconds and most people describe it as mildly uncomfortable but not painful.

The Water Cycles

Once the speculum is in place, warm filtered water (usually between 98 and 102 degrees Fahrenheit) begins flowing into the colon at low pressure. You’ll feel a sense of fullness, similar to needing to have a bowel movement. When the pressure builds to a comfortable threshold, the therapist opens the outflow valve and the water exits through a separate tube, carrying waste with it.

This fill-and-release cycle repeats multiple times throughout the session. The therapist adjusts water temperature slightly (alternating warmer and cooler water can stimulate peristalsis) and may massage your abdomen to help release material from specific areas [3].

Most people can see the waste exiting through the clear viewing tube on the machine. Therapists sometimes point out things like mucoid plaque, undigested food particles, or gas bubbles, though not all practitioners agree on the clinical significance of these observations. Gastroenterologists do not recognize “mucoid plaque” as a diagnosis.

Finishing Up

After the final release cycle, the therapist removes the speculum. You’ll use the restroom to expel any remaining water. Most facilities offer a probiotic supplement or implant (a small amount of probiotic solution introduced into the colon) at the end of the session, though this is optional.

The First 48 Hours After a Session

Most people feel lighter and may pass loose stools or gas for the rest of the day. Drinking water and eating simple, fiber-containing meals helps replace fluid and electrolytes. Severe abdominal pain, fever, rectal bleeding or dizziness after a colonic are not expected effects and need prompt medical care, because they can signal perforation or a serious fluid imbalance.

Proposed Benefits of Colon Hydrotherapy

The proposed benefits of colon hydrotherapy are relief of bloating and constipation, support for detoxification, a microbiome “reset,” more energy and clearer skin. Only the first two have small clinical studies behind them; the others rest on practitioner observation and on indirect research into the gut.

Bloating and Digestive Relief

The most immediately noticeable benefit that clients report is reduced bloating. By physically removing accumulated gas and stool from the colon, many people feel lighter and less distended within hours. A 2016 pilot study by Hsu and colleagues found that a colonic irrigation system provided symptomatic relief in patients with irritable bowel syndrome, including reduced abdominal distension and improved comfort [1]. A prospective study by Koch and colleagues (2008) in the British Journal of Surgery reported similar relief with colonic irrigation for defecation disorders [4].

For people dealing with chronic constipation, the mechanical action of water can stimulate peristalsis and help retrain sluggish bowel motility. Some practitioners report that a series of sessions can help establish more regular elimination patterns. Gastroenterologists usually start with fiber, fluids, osmotic laxatives and pelvic floor therapy, and the constipation treatment guide compares those options.

Detoxification Support

The colon is one of the body’s primary elimination organs. When transit time is slow and waste sits in the colon for extended periods, bacterial fermentation produces endotoxins (particularly lipopolysaccharide, or LPS) that can cross into the bloodstream through a compromised intestinal barrier. This process, often called endotoxemia, is linked to systemic inflammation, fatigue, and brain fog [5].

Proponents argue that colon hydrotherapy reduces the overall toxic burden by physically removing old fecal matter and reducing the reservoir of endotoxin-producing bacteria. The liver and kidneys handle most detoxification, and no controlled trial has measured lower endotoxin or toxin levels after a colonic. Regular, efficient bowel movements still matter for comfort and gut health, which is the part of this idea mainstream medicine accepts.

Gut Microbiome Reset

Some integrative practitioners use colon hydrotherapy as a “reset” before introducing targeted probiotics, dietary changes, or antimicrobial protocols. The idea is that clearing out dysbiotic bacteria and biofilm creates a cleaner environment for beneficial organisms to colonize [6].

This approach is not universally accepted. Critics point out that flushing the colon also removes beneficial bacteria. The closest data come from oral bowel preparation rather than colonics: Jalanka and colleagues (2015) gave 23 healthy adults a polyethylene glycol bowel prep and found the total microbial load fell 31-fold, while bacterial levels and community composition were essentially restored within 14 days [7]. No equivalent study of spa colonic irrigation has been published, so the size and duration of its effect on the microbiome are unknown.

Improved Energy and Mental Clarity

Many clients report feeling more alert and energetic after a colonic. The mechanism isn’t entirely clear, but reduced endotoxin circulation, decreased abdominal discomfort, and improved nutrient absorption are the explanations practitioners offer. The gut-brain axis is bidirectional, as Carabotti and colleagues (2015) describe, so reducing colonic discomfort and bacterial overgrowth could plausibly influence how you feel mentally, though no trial has tested this for colonics [8].

Skin Improvements

Practitioners frequently observe improvements in skin clarity among clients who complete a series of colonics. The gut-skin axis is well-documented in dermatological research; gut dysbiosis and increased intestinal permeability have been linked to acne, eczema, and rosacea [9]. No randomized controlled trial has specifically studied colon hydrotherapy for skin conditions, so the link remains a hypothesis. People with persistent acne or eczema have better studied options through a dermatologist.

What Does the Evidence Actually Say?

The clinical evidence for colon hydrotherapy is thin. Most of what exists comes from case series, practitioner surveys, and a handful of small studies.

The main systematic review, by Acosta and Cash in the American Journal of Gastroenterology (2009), searched both the conventional and the complementary medicine literature. The authors found no methodologically rigorous controlled trials supporting colonic cleansing for general health promotion, found multiple case reports and case series describing adverse effects, and concluded the practice could not be recommended for that purpose [10].

The stronger findings concern medical irrigation for specific bowel problems. Christensen and colleagues (2009) followed patients using transanal irrigation for constipation and fecal incontinence over the long term and reported lasting benefit in a share of patients, with serious complications uncommon [11]. Transanal irrigation is a prescribed, self-administered therapy, so these results support the mechanics of irrigation for those conditions rather than wellness colonics.

Most conventional gastroenterologists remain skeptical of colonics for general health, while integrative and functional medicine practitioners report positive experiences in their patients. Until controlled trials exist, client reports describe how people feel after a session, not whether the procedure changes long term health.

What has not been studied

Acosta and Cash found no eligible studies of colon cleansing for hypertension, asthma, irritable bowel syndrome, ulcerative colitis, arthritis or sinus congestion [10]. There are also no published trials comparing session frequency, water volume or added substances such as coffee, herbs or ozone, which some centers offer.

Is Colon Hydrotherapy FDA Approved?

The FDA regulates the machines used for colon hydrotherapy, not the procedure. Under federal rule 21 CFR 876.5220, a colonic irrigation system is a Class II device when it is intended for colon cleansing that is medically indicated, such as before a radiological or endoscopic examination. When the device is intended for other uses, including routine colon cleansing for general well being, it falls under Class III, which requires premarket approval.

In practice, device makers market their machines under the medical indication, and some US centers ask for a physician’s prescription before a first session. Colon hydrotherapy for detox, energy or weight loss is cash pay, and health insurance generally does not cover it. State rules on who may perform colonics vary, so ask what license or certification your therapist holds.

Risks and Side Effects

The common side effects of colon hydrotherapy are cramping, bloating, nausea and loose stools; the serious risks are electrolyte imbalance, bowel perforation and infection. Mishori and colleagues (2011) reviewed reported harms of colon cleansing in the Journal of Family Practice, from cramping and nausea to electrolyte problems and perforation [14].

Electrolyte Imbalance

Repeated sessions or excessively long sessions can disrupt electrolyte balance, particularly sodium and potassium levels. This risk increases in people who are already dehydrated, on diuretics, or fasting aggressively. Replenishing electrolytes after a session is standard practice [12].

Bowel Perforation

This is the most serious potential complication, though it is rare. A review of case reports found that perforation almost always occurred in the context of pre-existing bowel disease (such as severe diverticulosis), use of non-standard equipment, or practitioners without adequate training [13]. No reliable figure for how often it happens exists, because colonics are not tracked in any registry, and proper equipment and a qualified therapist lower the risk without removing it.

Infection

If equipment is not properly sanitized between patients, there is a risk of transmitting gastrointestinal infections. In the early 1980s, Istre and colleagues reported in the New England Journal of Medicine an outbreak of amebiasis spread by a colonic irrigation machine at a Colorado clinic. Disposable, single-use speculum kits and FDA-registered closed-system machines largely remove this risk. Always confirm that your practitioner uses disposable components [14].

Cramping and Discomfort

Mild cramping during the procedure is common, particularly during the first session. Some people experience loose stools, fatigue, or mild headache for 24 to 48 hours after a session. These symptoms are generally self-limiting. Practitioners often attribute them to the release of stored waste and toxins; fluid shifts and mild dehydration are the better documented explanations.

Disruption of Normal Flora

As mentioned earlier, flushing the colon does temporarily reduce bacterial populations. For healthy individuals, the microbiome recovers quickly. For people with already compromised gut health, following a colonic with high-quality probiotic supplementation and prebiotic-rich foods is prudent.

Interactions with medications

A colonic can shorten the time oral medicines spend in the gut and can add to the effect of diuretics. People taking blood thinners, diuretics, diabetes medicines or any drug with a narrow dosing range should check with the prescribing clinician before booking.

Who Should Avoid Colon Hydrotherapy?

Certain conditions make the procedure unsafe. You should not undergo colon hydrotherapy if you have:

  • Active inflammatory bowel disease (Crohn’s disease or ulcerative colitis in flare)
  • Severe diverticulitis or recent diverticular bleeding
  • Recent abdominal or colorectal surgery (within 3 to 6 months)
  • Colorectal cancer or large polyps
  • Severe hemorrhoids with active bleeding
  • Uncontrolled heart or kidney disease
  • Pregnancy
  • Abdominal hernia
  • Severe anemia

If you take blood thinners, have a history of bowel obstruction, or have any implanted abdominal devices, discuss the procedure with your physician before scheduling.

What professional contraindication lists include

Professional contraindication lists for colon hydrotherapy name severe anemia, congestive heart failure, uncontrolled high blood pressure, renal insufficiency, cirrhosis of the liver, aneurysm, anal fissures or fistulas, rectal bleeding, colorectal cancer, recent bowel surgery or biopsy, active inflammatory bowel disease and pregnancy. The list published for registered colon hydrotherapists by the UK Complementary and Natural Healthcare Council (CNHC) gives the reason for the anemia exclusion: risk of fainting. I-ACT’s standards of practice for US therapists also call for screening clients for contraindications before a session [15].

Anemia and colon hydrotherapy

Severe anemia is a contraindication because a session involves lying flat, fluid shifts and sometimes a vasovagal response, all of which can cause lightheadedness or fainting in someone with low red blood cells. Mild, treated anemia is usually a judgment for the treating physician. If you have anemia from bleeding in the gut, such as from hemorrhoids, polyps or inflammatory bowel disease, the cause needs a medical workup before any colonic.

When to see a doctor instead

Blood in the stool, unexplained weight loss, a change in bowel habit lasting more than a few weeks, or new constipation that starts in middle age or later are reasons to see a primary care physician or gastroenterologist first. These symptoms can point to conditions, including colorectal cancer, that a colonic would mask rather than treat.

Who Performs Colon Hydrotherapy?

Colon hydrotherapy is performed by colon hydrotherapists, many of them certified through the International Association for Colon Hydrotherapy (I-ACT), and it is offered in naturopathic, chiropractic, integrative and functional medicine practices and wellness centers. Some therapists are also nurses or licensed massage therapists. Gastroenterologists do not usually perform wellness colonics, but they order bowel preparation and transanal irrigation for medical reasons.

Licensing differs from state to state, and some states have no specific rule for colonics. Asking who supervises the center, which certification the therapist holds and whether a physician reviews contraindications tells you more than the setting does.

How to Find a Reputable Practitioner

The quality of your experience depends enormously on the practitioner and facility. Here’s what to look for:

  • Certification through I-ACT (International Association for Colon Hydrotherapy) or a similar nationally recognized body. I-ACT offers Foundation, Intermediate, and Instructor-level certifications [15].
  • Use of FDA-registered equipment, closed or open system, with a cleared intended use
  • Disposable, single-use speculum kits and tubing
  • A clean, professional facility that feels more like a medical office than a spa
  • Willingness to review your health history and screen for contraindications
  • Transparent pricing with no aggressive upselling of excessive session packages

Ask about the therapist’s training, how many sessions they’ve performed, and what infection control protocols they follow. A competent practitioner will welcome these questions rather than brushing them off.

The Regenerated.com colon hydrotherapy clinic list shows practitioners nationwide, and state pages narrow it down, for example colon hydrotherapy in California, New Jersey colon hydrotherapy clinics or practitioners in Oregon. Listing order is not paid ranking. Featured slots are labeled and capped, and Verified means the clinic completed credential checks, not that it spent money. Regenerated.com is free for patients, and inclusion in the directory is not an endorsement, so use the checklist above on any clinic you contact. The guide to Featured, Verified and organic listings explains each label.

The Bottom Line

Colon hydrotherapy is a long established procedure in the integrative health world, with a generally favorable safety profile when performed correctly on screened clients. Many people report genuine relief from bloating, constipation, and low energy. The evidence base is limited by a lack of large randomized trials, and the supportive findings that exist come from small studies and from medical irrigation for specific bowel disorders.

The key is approaching it with realistic expectations. A colonic does not fix every digestive problem, and it is not a substitute for dietary changes, hydration, fiber intake, and addressing root causes of digestive dysfunction. Used as one tool within a comprehensive gut health strategy, it can be a valuable addition for the right person.

If you decide to try it, choose a certified practitioner with proper equipment, disclose your full medical history, and pay attention to how your body responds. For many people, that first session answers the question definitively: they either feel noticeably better, or they decide it’s not for them.

Frequently asked questions

What are the benefits of colon hydrotherapy?

The benefits most people report from colon hydrotherapy are short term relief of bloating, gas and constipation, and a lighter, more comfortable abdomen after a session. Small studies, including a 2016 pilot in irritable bowel syndrome, support relief of bloating and bowel symptoms. Claims about detox, energy, weight loss and skin are not backed by controlled trials, and a 2009 systematic review by Acosta and Cash found no rigorous evidence of benefit for general health.

What are the side effects of colon hydrotherapy?

The most common side effects of colon hydrotherapy are cramping, bloating, nausea, loose stools, fatigue and mild headache for a day or two. Less common but serious risks are dehydration and electrolyte imbalance, bowel perforation and infection from poorly cleaned equipment. The serious risks are concentrated in people with existing bowel, heart or kidney disease, and in sessions run with nonstandard equipment or by untrained operators.

Can you have colon hydrotherapy if you have anemia?

Severe anemia is a contraindication to colon hydrotherapy on professional lists, including the colon hydrotherapy contraindications published by the UK Complementary and Natural Healthcare Council, because of the risk of fainting during or after a session. Mild, stable anemia is a decision for your physician. If the anemia comes from bleeding in the gut, the cause needs a medical workup first, since a colonic can delay a diagnosis such as polyps or colorectal cancer.

Is colon hydrotherapy FDA approved?

The FDA regulates colonic irrigation machines, not the procedure itself. Under 21 CFR 876.5220, the devices are Class II when used for medically indicated colon cleansing, such as before a colonoscopy or radiological exam. Use for routine cleansing and general well being falls under Class III, which requires premarket approval. A therapist describing a machine as FDA registered or cleared is not describing an approval for detox or wellness claims.

How often should you get colon hydrotherapy?

No evidence-based schedule for colon hydrotherapy exists, because no trial has compared session frequencies. Package offers of several sessions in a short period reflect practitioner habit rather than research. Each additional session adds to the risk of dehydration and electrolyte imbalance, so frequent colonics are a reason to involve a physician, especially for anyone on diuretics or with kidney or heart disease.

Is colon hydrotherapy the same as colonoscopy prep?

Colon hydrotherapy is not the same as colonoscopy preparation. Standard colonoscopy prep is an oral laxative solution, such as polyethylene glycol, that a gastroenterologist prescribes to clean the whole colon. Cleansing before an endoscopic exam is the medically indicated use the FDA names for colonic irrigation devices, but follow the prep instructions from the clinic performing your colonoscopy and ask before substituting a colonic.

Sources

  1. Hsu HH, Leung WK, Hu ML. “Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study.” Techniques in Coloproctology. 2016;20(8):551-557. doi:10.1007/s10151-016-1491-z ↩
  2. Chen TS, Chen PS. “The myth of Prometheus and the liver.” Journal of the Royal Society of Medicine. 1994;87(12):754-755. doi:10.1177/014107689408701213 ↩
  3. Taffinder NJ, Tan E, Webb IG, McDonald PJ. “Retrograde commercial colonic hydrotherapy.” Colorectal Disease. 2004;6(4):258-260. doi:10.1111/j.1463-1318.2004.00614.x ↩
  4. Koch SMG, Melenhorst J, van Gemert WG, Baeten CGMI. “Prospective study of colonic irrigation for the treatment of defaecation disorders.” British Journal of Surgery. 2008;95(10):1273-1279. doi:10.1002/bjs.6232 ↩
  5. Guo S, Al-Sadi R, Said HM, Ma TY. “Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14.” American Journal of Pathology. 2013;182(2):375-387. doi:10.1016/j.ajpath.2012.10.014 ↩
  6. Macfarlane S, Macfarlane GT, Cummings JH. “Review article: prebiotics in the gastrointestinal tract.” Alimentary Pharmacology and Therapeutics. 2006;24(5):701-714. doi:10.1111/j.1365-2036.2006.03042.x ↩
  7. Jalanka J, Salonen A, Salojärvi J, et al. “Effects of bowel cleansing on the intestinal microbiota.” Gut. 2015;64(10):1562-1568. doi:10.1136/gutjnl-2014-307240 ↩
  8. Carabotti M, Scirocco A, Maselli MA, Severi C. “The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.” Annals of Gastroenterology. 2015;28(2):203-209. PMID:25830558 ↩
  9. Salem I, Ramser A, Isham N, Ghannoum MA. “The gut microbiome as a major regulator of the gut-skin axis.” Frontiers in Microbiology. 2018;9:1459. doi:10.3389/fmicb.2018.01459 ↩
  10. Acosta RD, Cash BD. “Clinical effects of colonic cleansing for general health promotion: a systematic review.” American Journal of Gastroenterology. 2009;104(11):2830-2836. doi:10.1038/ajg.2009.494 ↩
  11. Christensen P, Krogh K, Buntzen S, et al. “Long-term outcome and safety of transanal irrigation for constipation and fecal incontinence.” Diseases of the Colon and Rectum. 2009;52(2):286-292. doi:10.1007/DCR.0b013e3181979341 ↩
  12. Picco MF, Cangemi JR. “Colonic cleansing: risky business?” American Journal of Gastroenterology. 2009;104(11):2836-2837. doi:10.1038/ajg.2009.525 ↩
  13. Handley DV, Rieger NA, Rodda DJ. “Rectal perforation from colonic irrigation administered by alternative practitioners.” Medical Journal of Australia. 2004;181(10):575-576. doi:10.5694/j.1326-5377.2004.tb06452.x ↩
  14. Mishori R, Otubu A, Jones AA. “The dangers of colon cleansing.” Journal of Family Practice. 2011;60(8):454-457. PMID:21814639 ↩
  15. International Association for Colon Hydrotherapy (I-ACT). “Standards of Practice and Code of Ethics.” Accessed 2025. https://www.i-act.org ↩

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