Read the Methylene Blue guide for the educational context behind this treatment category.
United States
This is the national page for methylene blue on Regenerated.com, listing clinics across the United States that record the treatment. Methylene blue, also called methylthioninium chloride, MB or methylene blue therapy, is a blue dye and medicine that can accept and donate electrons inside cells, which is why it is discussed in connection with mitochondrial energy production. In wellness and functional medicine settings it is usually given as a low dose by mouth, as a capsule, lozenge or liquid, and some clinics also offer it as a slow IV infusion. A physician, nurse practitioner or physician assistant prescribes it, a pharmacist or compounding pharmacy prepares it, and a nurse runs any infusion. People often compare it with NAD IV therapy, red light therapy, hyperbaric oxygen therapy (HBOT), peptide therapy and IV vitamin protocols.
The evidence picture depends on the use. Methylene blue is FDA approved as an IV medicine for acquired methemoglobinemia, a blood disorder in which red cells cannot carry oxygen well, and hospitals also use it off label in some cases of shock and as a surgical dye. The uses most patients search for, such as brain fog, memory, mood, fatigue, long COVID and healthy aging, are investigational. Researchers including Francisco Gonzalez-Lima at the University of Texas at Austin have published small human studies on low dose methylene blue and memory, and a related compound tested in late stage Alzheimer's disease trials did not meet its main goals. Low dose wellness products are often compounded and are not FDA approved for these purposes, so claims should be weighed against how limited the human data still is.
Candidates are generally adults in stable health who have completed a medical intake, shared a full medication list and accept that benefits are uncertain. The biggest safety issue is serotonin syndrome: the FDA has warned that methylene blue can interact dangerously with SSRIs, SNRIs, MAO inhibitors and some other antidepressants and pain medicines. People with G6PD deficiency, people who are pregnant or breastfeeding, and people with significant kidney disease are usually told not to take it, and anyone on psychiatric medication should involve their prescribing clinician first. Blue or green urine is a common, expected effect.
Methylene blue is offered in integrative and functional medicine practices, longevity and anti aging clinics, IV lounges and infusion suites, medical spas, and some telehealth programs that prescribe oral doses. Hospital programs use it for approved and acute indications rather than as a wellness service. Listings tend to concentrate in large Sun Belt and coastal metros, including South Florida, Southern California, the large Texas metros, Phoenix and Scottsdale, and the New York area, and many patients travel or start with a telehealth visit.
Before booking anywhere, ask who prescribes it and which physician supervises the clinic, and check those licenses yourself. Ask exactly what is administered, the dose, the route, and whether it is a pharmaceutical grade product from a licensed pharmacy rather than an industrial or aquarium grade dye. Ask for written disclosure of risks, including drug interactions, G6PD screening, nausea, headache and skin or urine discoloration. A clear quote itemizes the visit, the product, any IV or light therapy add on, lab work and package terms, and a clear plan says how the clinician will follow up.
This national list is not for sale. Organic order is never paid ranking, Featured slots are labeled and capped, and Verified means the clinic completed credential checks, not that it spent money. Regenerated.com is free for patients, and inclusion in the directory is not an endorsement. Use the state hubs below the list to build a shortlist closer to you.
For mechanism, dosing forms and safety in more depth, read the methylene blue guide. Two short explainers cover how listings work here: How to read a Regenerated city hub and Featured vs Verified vs organic.
