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3 Best Psychedelic Therapy Clinics in Houston, Texas

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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Houston, TX

Psychedelic Therapy clinics in Houston

Houston has 5 providers offering psychedelic therapy, with ketamine-assisted psychotherapy as the dominant nationwide option. Ketamine is FDA-approved as an anesthetic and Spravato (esketamine) is FDA-approved for treatment-resistant depression, while ketamine-assisted psychotherapy (KAP) is practiced off-label by licensed clinicians. In Texas, ketamine-assisted psychotherapy is the only medically available psychedelic option. Psilocybin and MDMA remain Schedule I federally. Psilocybin is legal only in Oregon and Colorado under state programs. MDMA-assisted therapy was not approved by the FDA in August 2024 after a Complete Response Letter to Lykos Therapeutics. Houston clinics commonly pair ketamine infusions or IM injections with therapy sessions, typical packages run 2,500 to 6,000 dollars for a six-session protocol, and Spravato is covered by many insurers when criteria are met. Psilocybin and MDMA remain federally illegal, and the FDA issued a Complete Response Letter to Lykos Therapeutics in August 2024 for MDMA-assisted therapy for PTSD. A reputable Houston provider will screen for cardiovascular risk, psychiatric history, and concurrent medications before starting treatment.

3 Clinics

Modern Therapy

Houston, TX

Modern Therapy, a mental health practice in Houston, specializes in psychedelic-assisted therapy for high-achieving professionals. The clinic offers evidence-based protocols that integrate psychedeli…

  • Psychedelic Therapy

Deep Eddy Psychotherapy

Houston, TX

Deep Eddy Psychotherapy, a Ketamine & Psychedelic-Assisted Therapy Clinic in Houston, offers esketamine and intramuscular ketamine infusions alongside psychedelic-assisted psychotherapy for treatment…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Psychedelic Therapy

Lauren Donelson Therapy

Houston, TX

Lauren Donelson Therapy, based in Houston, offers Internal Family Systems (IFS) therapy alongside psychedelic-assisted psychotherapy and astrology counseling. IFS is a structured therapeutic approach…

  • Psychedelic Therapy
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Regulatory context

A note on Texas's psychedelic therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • HB 1802 / Psilocybin and MDMA Research (2021)
    Required Texas Health and Human Services Commission to study psilocybin and MDMA for PTSD treatment in veterans; report completed.
  • Texas Ibogaine Initiative (HB 3717, 2025 pending)
    Would allocate $50 million for FDA-regulated ibogaine clinical trials, potentially the largest state psychedelic research investment in US history.
  • Texas Controlled Substances Act
    Mirrors federal scheduling.

Texas enforces federal scheduling. The Texas Medical Board oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Texas PMP requires controlled substance reporting. Texas has seen rapid ketamine clinic growth in Austin, Dallas, and Houston markets with corresponding enforcement attention on compounding and telehealth practices.

Sources: dea.gov · tmb.state.tx.us · pharmacy.texas.gov · capitol.texas.gov

Psychedelic Therapy in Houston, answered.

In Texas, ketamine-assisted psychotherapy is the primary legal option. Ketamine is a Schedule III controlled substance prescribed off label for depression, anxiety, and PTSD. Psilocybin and MDMA are Schedule I federally and not legally available in Texas. Only Oregon (Measure 109) and Colorado (Proposition 122) currently operate regulated psilocybin programs.

In Houston, ketamine-assisted psychotherapy typically runs 400 to 900 dollars per session, with full protocols of six sessions costing 2,500 to 6,000 dollars. IM injection sessions tend to be less expensive than IV infusions. Spravato (esketamine nasal spray) is FDA-approved for treatment-resistant depression and may be covered by insurance with prior authorization, though out-of-pocket copays vary. Integration therapy sessions are often billed separately at 150 to 300 dollars each.

Not as an FDA-approved treatment. In August 2024 the FDA issued a Complete Response Letter to Lykos Therapeutics (formerly MAPS PBC) for MDMA-assisted therapy for PTSD, citing concerns about trial design and data quality. MDMA remains Schedule I federally. Some expanded access and clinical trial pathways exist, but no Houston clinic can legally prescribe MDMA outside of those frameworks. Lykos has stated it plans to resubmit following additional trial work.

Ketamine-assisted psychotherapy is used off-label for treatment-resistant depression, PTSD, anxiety, and suicidal ideation. Spravato (esketamine) carries FDA approval specifically for treatment-resistant depression and major depressive disorder with acute suicidal ideation or behavior. Evidence quality is strongest for depression, with multiple randomized trials supporting short-term benefit. Houston clinics typically screen for cardiovascular conditions, psychotic disorders, and active substance use before starting treatment.

Verify the prescriber on the Texas medical board license lookup and NPI registry. Confirm the clinician has training in psychedelic-assisted therapy through MAPS, Fluence, Polaris, or a comparable program. Ask about screening protocols, emergency procedures, and whether a therapist is present during sessions. Check the FDA warning letter database. Avoid clinics promising guaranteed outcomes, pushing large prepaid packages, or operating outside of state licensure. Integration support should be part of any reputable protocol.

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