14 Best Ketamine Therapy Clinics in Houston, Texas (2026)

What does this directory page list?

This page lists directory records associated with Ketamine Therapy in the Houston, Texas browsing area. A browsing area can include nearby municipalities. Confirm each clinic's street address and current services directly.

Matching records:

14. Source: the current directory result set, including pages beyond this screen.

Treatment filter:

Ketamine Therapy.

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Listing information is not an independent clinic evaluation. Record updates do not establish field-level check dates.

Read the Ketamine Therapy guide for the educational context behind this treatment category.

Ketamine Therapy clinics in Houston

Ketamine for depression is offered at clinics across the Houston metro, though not in one obvious district: most clinics treating depression with ketamine are concentrated in a few medical and wellness corridors rather than spread evenly across the metro. The Texas Medical Center area near downtown, reached from I-45 and the 610 Loop, has several psychiatry-affiliated offices. Uptown and the Galleria, along Post Oak Boulevard and Westheimer Road, host another concentration, and the Memorial area near I-10 draws patients from the west side. Suburban practices are common too, in The Woodlands north on I-45, Sugar Land southwest on US-59, and Katy west along I-10 or the Grand Parkway. Confirm the exact address before booking, since a Galleria-area suite and a Woodlands medical office are different settings even if both treat depression.

Locally, intravenous ketamine for depression is given in a monitored medical setting, usually a psychiatric or infusion clinic rather than a general wellness studio. A prescriber and clinical staff should oversee the infusion and your recovery, and a first visit typically covers a psychiatric and medical history, current medications, and a conversation about what you are hoping the treatment will change. Ask directly whether a Houston provider offers IV ketamine, nasal esketamine, or ketamine paired with talk therapy, since these differ in monitoring, staffing, and cost. Follow-up should track your response over time rather than lock you into a fixed number of sessions from the start.

Before booking anywhere in the Houston area, ask who prescribes and who stays in the room during infusions, where the medication is sourced from, and how side effects and risks are put in writing. Ask what happens if the treatment does not help, and request an itemized quote separating the evaluation, the medication, monitoring, and any therapy sessions.

Regenerated.com does not sell placement on this page: the order clinics appear in is not paid ranking, Featured spots are labeled and limited in number, and Verified means a clinic's credentials have been checked, not that it paid more. Regenerated.com is free for patients to use, and appearing in this directory is not an endorsement of any clinic.

For the mechanism and broader evidence behind the treatment, see the national ketamine therapy hub. For more on how to read this list, see How to read a Regenerated city hub and Featured vs Verified vs organic.

A note on Texas's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

HB 1802 / Psilocybin and MDMA Research (2021)
Required Texas Health and Human Services Commission to study psilocybin and MDMA for PTSD treatment in veterans; report completed.
Texas Ibogaine Initiative (HB 3717, 2025 pending)
Would allocate $50 million for FDA-regulated ibogaine clinical trials, potentially the largest state psychedelic research investment in US history.
Texas Controlled Substances Act
Mirrors federal scheduling.

Texas enforces federal scheduling. The Texas Medical Board oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Texas PMP requires controlled substance reporting. Texas has seen rapid ketamine clinic growth in Austin, Dallas, and Houston markets with corresponding enforcement attention on compounding and telehealth practices.

Ketamine Therapy in Houston, answered.

Ketamine therapy usually means a low, controlled dose of ketamine given by IV, as a nasal spray, or occasionally by other routes in a monitored medical setting, often paired with psychiatric support. In Houston, that setting is generally a psychiatry-affiliated office or infusion suite in areas like the Texas Medical Center, Uptown, or Memorial, with staff monitoring vital signs and your response throughout the visit.

Ketamine is thought to affect glutamate signaling in ways that differ from standard antidepressants, which is part of why it is considered for depression that has not responded to other treatment. A first Houston visit generally includes a psychiatric and medical history, a review of current medications, and a discussion of goals, with follow-up visits used to track your response rather than following a fixed, pre-set schedule.

Common short-term effects include dissociation, dizziness, nausea, and changes in blood pressure during and shortly after the infusion, which is why monitoring and a recovery period are part of a properly run session. Longer-term or recurring use raises separate questions about bladder and cognitive effects that a prescriber should discuss with you directly rather than leaving to a pamphlet.

Adults whose depression, anxiety, or related symptoms have not improved enough with standard treatment are often considered after a full psychiatric and medical evaluation, and some providers also assess patients for bipolar-related depression or substance use concerns on a case by case basis. Uncontrolled high blood pressure, certain heart conditions, pregnancy, active psychosis, or significant uncontrolled substance use commonly lead a provider to recommend postponing or avoiding treatment.

IV ketamine for depression is generally cash pay in Houston, while coverage for nasal esketamine, psychiatric evaluations, or accompanying psychotherapy depends on your specific plan and network. A written quote should separate the evaluation, medication, monitoring, and any therapy or follow-up charges, and costs vary enough by provider and setting that this page does not publish an average.

Look for a licensed physician, nurse practitioner, or psychiatric provider who is present or directly supervising during the infusion, along with clear written protocols for monitoring and emergencies. You can verify a Texas medical or nursing license through the relevant state licensing board's public lookup before booking, and a legitimate clinic should not hesitate to confirm who is overseeing your care.

Ketamine itself is an approved anesthetic that physicians can prescribe off-label for conditions like depression, and esketamine has separate FDA approval specifically for treatment-resistant depression when given under supervision. Off-label use being legal is not the same as a treatment being proven for every condition it is marketed for, so ask a Houston provider directly what evidence supports its use for your specific situation.

This page lists clinics that treat patients in the Houston area specifically, with organic order that is not sold and Featured placements that are labeled and capped separately from the rest of the list. A general web search mixes paid ads, directories, and unverified listings together, while Verified status here reflects a credential check rather than how much a clinic has spent on marketing.

14 Best Ketamine Therapy Clinics in Houston, Texas

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

What does this directory page list?

Ketamine Therapy clinics in Houston

14 Clinics

Houston Mind & Brain

713 Wellness, Aesthetics and Medical Center

PUUR Health and Wellness

Deep Eddy Psychotherapy

Cendant Stem Cell Center

Esketamine Spravato Treatment Center

Your Wellness Practice - Integrative Psychiatry, Ketamine, TMS.

Texas Ketamine & Wellness Center

Principle Spine and Pain

Janet Varela Colletto MS, LPC

Greater Heights Holistic Psychiatry

Lone Star Infusion

Laura Wiginton

NeuMed Modern Urgent Care + IV Therapy, Heights

A note on Texas's ketamine therapy rules.

Ketamine Therapy in Houston, answered.

Ketamine Therapy in nearby Cities

Other Treatments available in Houston

14 Best Ketamine Therapy Clinics in Houston, Texas

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

What does this directory page list?

Ketamine Therapy clinics in Houston

14 Clinics

A note on Texas's ketamine therapy rules.

Ketamine Therapy in Houston, answered.

What is ketamine therapy, and how is it typically done at a Houston clinic?

How does ketamine therapy for depression work, and what does a first visit cover?

What are the side effects of ketamine therapy?

Who is generally considered a good candidate for ketamine therapy, and who is usually told to wait?

How much does ketamine therapy cost in Houston, and is it covered by insurance?

What credentials and supervision should a Houston ketamine provider have, and how can I check a license in Texas?

Is ketamine therapy legal, and how is that different from FDA approval?

How does this Regenerated.com Houston page differ from a general search for ketamine therapy providers?

Ketamine Therapy in nearby Cities

Other Treatments available in Houston