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5 Best Ketamine Therapy Clinics in Cleveland, Ohio

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

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What does this directory page list?

This page lists directory records associated with Ketamine Therapy in the Cleveland, Ohio browsing area. A browsing area can include nearby municipalities. Confirm each clinic's street address and current services directly.

Matching records:
5. Source: the current directory result set, including pages beyond this screen.
Treatment filter:
Ketamine Therapy.
Source limits:
Listing information is not an independent clinic evaluation. Record updates do not establish field-level check dates.

Read the Ketamine Therapy guide for the educational context behind this treatment category.

Cleveland, OH

Ketamine Therapy clinics in Cleveland

If you searched for the best ketamine clinic in Cleveland, the honest answer is that this page will not name one, even though it currently lists five local providers. "Best" depends on your diagnosis, which formulation fits your case, and how a specific team handles monitoring and follow-up, not a single ranked pick. Choosing a provider for ketamine therapy in Cleveland starts with matching the service to your diagnosis, the clinical supervision, and the trip home. Psychiatric and behavioral health practices cluster along the University Circle corridor near Euclid Avenue, close to the city's major hospital campuses, as well as in the eastern suburbs: outpatient infusion services operate around Commerce Park in Beachwood, near the Chagrin Boulevard corridor and I-271. For someone coming from Lakewood, Rocky River, or another western suburb reached by I-90, compare the actual treatment address before committing to repeated trips across the metro. Arrange an adult to take you home after treatment and allow for observation before pickup.

Local options include medical offices and infusion suites, where licensed clinical staff administer IV medication under a prescriber's treatment plan. Confirm whether the service is intravenous ketamine, nasal esketamine, or ketamine paired with psychotherapy. An initial assessment should review previous depression treatments, medications, medical history, blood pressure, and current mental health symptoms. Follow-up should track both symptom changes and adverse effects, with coordination between the treatment team and your usual mental health clinician.

Ask who prescribes, who stays available during treatment, and what training staff have in managing complications. Request the medication's exact formulation and source, written information about risks and side effects, and a plan for stopping or changing treatment if it does not help. Get a written quote showing what is included and which assessments, monitoring, psychotherapy, or follow-up appointments carry separate charges. IV ketamine for depression is an off-label use, meaning it lacks FDA approval for that purpose, and is commonly cash pay; longer-term evidence remains limited.

Organic listing order on Regenerated.com cannot be bought. Featured placements are labeled and capped, while Verified indicates credential checks rather than advertising spend. Regenerated.com is free for patients, and inclusion in this directory does not endorse a provider.

The national ketamine therapy hub explains the treatment's mechanism and broader evidence. Use How to read a Regenerated city hub and Featured vs Verified vs organic to interpret the listings and their labels.

5 Clinics

Cleveland Pain Care
Physician reported in record

Cleveland Pain Care

Cleveland, OH

Cleveland Pain Care, a regenerative medicine clinic in Mayfield Heights, Ohio, offers stem-cell injections and platelet-rich plasma therapy for musculoskeletal pain, joint conditions, and soft-tissue…

  • PRP Therapy
  • IV Therapy
  • Ketamine Therapy
  • Arthritis Treatment
  • Stem Cell Therapy
Kristin A Hunt LISW - Heart Centered Therapy
(3) Physician status unknown

Kristin A Hunt LISW - Heart Centered Therapy

Cleveland, OH

Kristin A Hunt LISW – Heart Centered Therapy, a ketamine-therapy clinic in Westlake, offers ketamine-assisted psychotherapy for treatment-resistant anxiety, PTSD, and related mood and trauma presenta…

  • Ketamine Therapy
Larchmere Center for Well-being
(30) Physician status unknown

Larchmere Center for Well-being

Cleveland, OH

Larchmere Center for Well-being, an inclusive and affirming mental-health practice in Cleveland, Ohio, specializes in Ketamine Therapy for treatment-resistant depression, anxiety, and related conditi…

  • Ketamine Therapy
D2 Human Performance Centers
(7) Physician status unknown

D2 Human Performance Centers

Cleveland, OH

D2 Human Performance Centers, located in Broadview Heights, Ohio, offers cryotherapy, red-light therapy, and biofeedback alongside detoxification protocols. The clinic combines these modalities to su…

  • Biofeedback Therapy
  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Cryotherapy
  • Red Light Therapy
Renaissance Behavioral Health
(85) Physician status unknown

Renaissance Behavioral Health

Cleveland, OH

Renaissance Behavioral Health, a ketamine-therapy clinic in Cleveland, offers ketamine treatment for patients with treatment-resistant depression, anxiety, and post-traumatic stress. The clinic posit…

  • Ketamine Therapy
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Regulatory context

A note on Ohio's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • Ohio Controlled Substances Act (ORC Chapter 3719)
    Mirrors federal scheduling; no therapeutic access framework.

Ohio enforces federal scheduling. The State Medical Board of Ohio oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Ohio OARRS PDMP requires controlled substance reporting. Ohio has strict office-based anesthesia rules for procedures involving moderate or deep sedation.

Sources: dea.gov · med.ohio.gov · pharmacy.ohio.gov · codes.ohio.gov

Ketamine Therapy in Cleveland, answered.

IV ketamine for depression is commonly paid for out of pocket. Nasal esketamine and associated psychiatric care may have coverage, depending on your plan, authorization requirements, and provider network. Ask Cleveland offices to itemize assessment, medication, administration, observation, psychotherapy, and follow-up. Staffing, formulation, and setting affect the total, so this page does not publish an average that could combine substantially different services.

Adults with depression that has not improved sufficiently with standard care may be considered after psychiatric and medical screening. Uncontrolled blood pressure, certain cardiovascular conditions, active psychosis, pregnancy, or concerns about substance misuse may lead to postponement or another approach. A Cleveland prescriber should review your individual risks and prior treatment records, rather than determine eligibility from symptoms on a booking form alone.

An IV delivers ketamine while clinical staff monitor your condition, including blood pressure and breathing, followed by observation before discharge. The care plan should explain how appointments are scheduled and when progress will be reviewed. Ask who handles concerns between visits and how the team decides whether to continue, adjust, or stop treatment. For a Beachwood appointment, build the return trip and your driver's availability into that plan.

Ketamine can cause nausea, dizziness, sedation, increased blood pressure, and dissociation, a feeling of detachment from your body or surroundings. Breathing problems can occur, and repeated exposure raises concerns about misuse and bladder symptoms. Ask for written instructions about symptoms to report, urgent help, and restrictions after treatment. Monitoring reduces some risks but does not eliminate them; arrange a ride and follow the clinician's driving instructions.

Ask for the names and license numbers of the prescriber and professionals administering treatment. Use Ohio's eLicense lookup, selecting the Medical Board or Nursing Board as appropriate, to check active status and available disciplinary records. Also ask about experience treating your diagnosis, monitoring responsibilities, and emergency procedures. A current license alone does not establish expertise in ketamine treatment or psychiatric follow-up.

Research supports rapid symptom improvement for some adults with treatment-resistant depression, but responses vary and benefits may fade. Evidence is less settled for prolonged IV maintenance and for conditions such as PTSD or addiction. IV ketamine is not FDA approved for depression; nasal esketamine has approval for specific depressive indications and requires supervised administration. Ask how the provider measures improvement and what alternatives remain if symptoms persist.

Use this local directory to compare locations and the services each listing describes, then confirm details directly with the office. The national hub covers mechanisms and evidence; this page helps with practical Cleveland choices, including travel to suburban appointments. Unlike a broad web search that mixes advertisements, research, and remote services, the directory brings local listings together. Inclusion does not establish suitability for your diagnosis.

A Featured label identifies a promotional placement, and those placements are labeled and capped. It does not establish greater clinical skill. Organic order is not sold, and Verified reflects credential checks rather than payment or a promise of results. Regenerated.com is free for patients. Compare supervision, relevant experience, and follow-up arrangements yourself, regardless of a listing's position or badge.

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