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10 Best Ketamine Therapy Clinics in Nashville, Tennessee

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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Nashville, TN

Ketamine Therapy clinics in Nashville

Ketamine therapy in Nashville is delivered through psychiatry-led clinics, anesthesia-run infusion centers, and ketamine-assisted psychotherapy practices, with hospital referrals often tied to Vanderbilt University Medical Center, Saint Thomas Health, and HCA TriStar. Demand reflects a healthcare-industry and music-industry professional population and an active local market for treatment-resistant depression, PTSD, and chronic pain.

The strongest evidence supports intranasal esketamine (Spravato, FDA-approved for treatment-resistant depression) and intravenous racemic ketamine (off-label, substantial supporting evidence). Clinics in Nashville, Tennessee also offer intramuscular, sublingual, and at-home oral lozenge protocols, with weaker evidence and variable safety oversight. Tennessee Department of Health rules on office-based procedures and stem cell claims shapes which clinics can operate as cash-pay versus insurance-eligible.

With ketamine clinics on Regenerated.com in Nashville, patients can compare whether the clinic offers psychiatric evaluation, anesthesia monitoring during infusion, and structured preparation and integration.

10 Clinics

MD on staff

61Five Health & Wellness

Nashville, TN

61Five Health & Wellness, an IV therapy clinic in Nashville, offers a comprehensive array of regenerative and supportive-medicine treatments centered on cell-based therapies, peptide protocols, and I…

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy

Drip Hydration

Nashville, TN

Drip Hydration, an IV therapy clinic in Nashville, offers on-demand mobile infusions delivered to home, office, or hotel settings. The practice specializes in IV nutrient therapy including Myers Cock…

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • IV Therapy
 MD on staff

Nashville Ketamine

Nashville, TN

Nashville Ketamine, a Ketamine Therapy Clinic in Nashville, specializes in ketamine infusion for treatment-resistant depression, including unipolar and bipolar presentations. The clinic offers indivi…

  • Ketamine Therapy

Music City Therapy

Nashville, TN

Music City Therapy, led by Thomas D. Neilson, PsyD, a licensed clinical psychologist in Nashville, specializes in ketamine-assisted psychotherapy and integrative mental-health treatment. The practice…

  • Ketamine Therapy

The Dragonfly Nest

Nashville, TN

The Dragonfly Nest, a Ketamine Therapy Clinic in Nashville, specializes in ketamine-assisted treatment for trauma and related mental-health conditions. The practice frames care around holistic trauma…

  • Ketamine Therapy

Simply Being

Nashville, TN

Simply Being, a ketamine and psychedelic-assisted therapy clinic in Nashville, offers ketamine therapy for treatment-resistant depression, anxiety, and PTSD alongside integrative supportive care. The…

  • PRP Therapy
  • Ketamine Therapy
  • Arthritis Treatment
  • Psychedelic Therapy
  • Hormone Replacement Therapy (HRT)
 MD on staff

Nashville Center for Hope & Healing

Nashville, TN

Nashville Center for Hope & Healing offers ketamine therapy and transcranial magnetic stimulation (TMS) for treatment-resistant depression, anxiety, and related mental-health conditions. The clinic p…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy

MindStream Integrative Medicine

Nashville, TN

MindStream Integrative Medicine in Nashville offers functional and integrative medicine with a focus on IV therapy and ketamine-assisted treatment for patients with treatment-resistant depression, an…

  • IV Therapy
  • Ketamine Therapy

Vida-Flo

Nashville, TN

Vida-Flo Nashville, an IV therapy clinic in Nashville, offers a comprehensive menu of intravenous infusions and ozone protocols designed to support wellness, energy, immune function, and longevity. T…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • Ozone Therapy
  • IV Therapy
  • IV Hydration
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Regulatory context

A note on Tennessee's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • SB 2778 / Psilocybin Research and Treatment (2022)
    Authorized clinical research on psilocybin for treatment-resistant depression and PTSD at Tennessee academic institutions.
  • Tennessee Drug Control Act
    Mirrors federal scheduling.

Tennessee enforces federal scheduling. The Tennessee Board of Medical Examiners oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Tennessee CSMD PDMP requires controlled substance reporting.

Sources: dea.gov · tn.gov · tn.gov · wapp.capitol.tn.gov

Ketamine Therapy in Nashville, answered.

In Nashville, a single IV ketamine infusion typically runs 500 to 900 dollars, with a full 6 session induction protocol at 3,000 to 5,400. Premium clinics on the higher end, more affordable providers on the lower end. Intramuscular ketamine often costs less, around 250 to 500 per session. Compounded ketamine lozenges via telehealth run 250 to 500 per month. Spravato (esketamine) is frequently covered by insurance for treatment resistant depression; out of pocket list price is roughly 600 to 900 per treatment session, with most patients paying a copay.

Ketamine is a Schedule III controlled substance and has been FDA approved as an anesthetic since 1970. Spravato (esketamine), a derivative nasal spray, is FDA approved for treatment resistant depression under a REMS program requiring in clinic administration and post dose monitoring. IV, intramuscular, and compounded oral ketamine for depression, PTSD, and chronic pain are used off label with Emerging to Strong evidence depending on indication. Off label prescribing is legal for DEA registered providers but must follow state and federal controlled substance rules.

Nashville ketamine is delivered by MDs and DOs (typically psychiatrists, anesthesiologists, emergency medicine, or pain specialists) holding a DEA registration and Tennessee controlled substance authority. Nurse practitioners and physician assistants may prescribe or administer depending on Tennessee scope of practice and supervisory rules. Spravato requires a REMS certified clinic and certified prescriber. Verify the provider's DEA registration, board certification, and whether a monitoring clinician is present during infusions.

Yes, with caveats. Mindbloom, Joyous, Innerwell, and similar platforms prescribe compounded ketamine lozenges to Tennessee residents through telehealth, subject to the Ryan Haight Act and DEA special registration rules currently in effect. These programs pair at home dosing with virtual integration support and cost roughly 250 to 500 per month. In clinic IV and intramuscular ketamine remain the standard for treatment resistant depression and PTSD and cannot be delivered via telehealth. Spravato always requires in clinic REMS administration.

Verify DEA registration on the DEA Office of Diversion Control registrant lookup and Tennessee medical board license status. Confirm board certification in psychiatry, anesthesiology, emergency medicine, or pain medicine. Ask about the monitoring protocol during infusion (vitals, continuous clinician presence), integration therapy options, and the clinic's crisis and safety plan. Check whether the clinic is Spravato REMS certified if that is your treatment path. Be cautious of providers who skip screening, push large prepaid packages, or offer take home IV ketamine.

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