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15 Best Ketamine Therapy Clinics in Houston, Texas

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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Houston, TX

Ketamine Therapy clinics in Houston

Houston has multiple clinics offering ketamine therapy, a fast growing segment for treatment resistant depression, PTSD, chronic pain, and anxiety. Texas requires an in person evaluation for Schedule III telehealth prescribing under current DEA rules; most ketamine in Texas is delivered in clinic. Most Houston clinics deliver IV ketamine infusions in a monitored clinical setting, typically across a 6 session induction protocol, followed by maintenance infusions. Spravato (esketamine), the FDA approved nasal spray for treatment resistant depression, is available in Houston only at REMS certified clinics and is often covered by insurance when medical necessity is documented. Compounded ketamine lozenges and troches are also prescribed in Houston, sometimes through telehealth platforms like Mindbloom, Joyous, and Innerwell, subject to Ryan Haight Act and DEA special registration considerations. Local pricing in Houston sits in the standard range: single IV infusions run 500 to 900 dollars, a full 6 session protocol lands at 3,000 to 5,400, and Spravato copays depend on insurance coverage. A reputable Houston ketamine clinic will pair pharmacology with integration support, monitor vitals during infusion, and have a clear crisis and follow up plan.

15 Clinics

MD on staff

Houston Mind & Brain

Houston, TX

Houston Mind & Brain, a ketamine and psychedelic-assisted therapy clinic in Houston, offers ketamine infusion therapy and Spravato (esketamine) nasal spray for treatment-resistant depression, anxiety…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
MD on staff

713 Wellness, Aesthetics and Medical Center

Houston, TX

713 Wellness, Aesthetics and Medical Center in Houston offers IV nutrient therapy, NAD+ infusions, and ketamine therapy alongside hormone replacement therapy and bioidentical-hormone protocols. The p…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • IV Therapy
  • IV Hydration
MD on staff

PUUR Health and Wellness

Houston, TX

PUUR Health and Wellness, an IV therapy and integrative-wellness clinic in Houston, specializes in intravenous nutrient protocols including Myers Cocktail infusions, NAD+ therapy, and targeted vitami…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • IV Therapy
  • IV Hydration
  • Ketamine Therapy

Deep Eddy Psychotherapy

Houston, TX

Deep Eddy Psychotherapy, a Ketamine & Psychedelic-Assisted Therapy Clinic in Houston, offers esketamine and intramuscular ketamine infusions alongside psychedelic-assisted psychotherapy for treatment…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Psychedelic Therapy
MD on staff

Cendant Stem Cell Center

Houston, TX

Cendant Stem Cell Center, a regenerative medicine clinic in Houston, offers a comprehensive range of stem-cell and cell-based therapies including bone-marrow stem-cell concentrate, adipose-derived st…

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Shockwave Therapy
MD on staff

Esketamine Spravato Treatment Center

Houston, TX

Esketamine Spravato Treatment Center in Houston specializes in esketamine and ketamine therapy for treatment-resistant depression, alongside transcranial magnetic stimulation (TMS). The clinic offers…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy

Your Wellness Practice - Integrative Psychiatry, Ketamine, TMS.

Houston, TX

Your Wellness Practice—Integrative Psychiatry, Ketamine, TMS in Houston specializes in ketamine-assisted therapy for treatment-resistant depression, anxiety, and PTSD, alongside transcranial magnetic…

  • IV Therapy
  • Transcranial Magnetic Stimulation (TMS)
  • Neurofeedback Therapy
  • Ketamine Therapy
  • Hormone Replacement Therapy (HRT)
MD on staff

Texas Ketamine & Wellness Center

Houston, TX

Texas Ketamine & Wellness Center, located in Houston, offers physician-guided ketamine therapy for treatment-resistant depression, PTSD, anxiety, obsessive-compulsive disorder, and chronic pain condi…

  • IV Therapy
  • Ketamine Therapy
  • Migraine Treatment
MD on staff

Bespoke Health - Relief, tailored to you.

Houston, TX

Bespoke Health, an IV therapy clinic in Houston, specializes in intravenous nutrient protocols and NAD IV therapy for patients managing chronic fatigue and seeking supportive care. The practice offer…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • IV Therapy
  • IV Hydration
  • Ketamine Therapy

Principle Spine and Pain

Houston, TX

Principle Spine and Pain, a pain management clinic in the Houston area, offers stem-cell therapy and ketamine therapy for patients with chronic pain and treatment-resistant conditions. The clinic com…

  • Ketamine Therapy
  • Arthritis Treatment
  • Migraine Treatment
  • Stem Cell Therapy
MD on staff

Janet Varela Colletto MS, LPC

Houston, TX

Janet Varela Colletto, MS, LPC, a counselor in Houston, specializes in ketamine-assisted psychotherapy for individuals, couples, and groups. The practice offers ketamine therapy integrated with psych…

  • Ketamine Therapy
  • Hormone Replacement Therapy (HRT)

Wells Medicine

Houston, TX

Wells Medicine, an interventional mental-health clinic in Houston, specializes in ketamine-assisted therapy and psychedelic-assisted protocols for treatment-resistant depression, anxiety, OCD, and PT…

  • IV Therapy
  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Stem Cell Therapy
MD on staff

Greater Heights Holistic Psychiatry

Houston, TX

Greater Heights Holistic Psychiatry, a neuromodulation clinic in Houston, specializes in Transcranial Magnetic Stimulation (TMS) for treatment-resistant depression and anxiety. TMS uses magnetic puls…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
MD on staff

Lone Star Infusion

Houston, TX

Lone Star Infusion, a ketamine-therapy clinic in Houston, specializes in ketamine infusion protocols for treatment-resistant depression, anxiety, and post-traumatic stress. The clinic offers ketamine…

  • Ketamine Therapy

Laura Wiginton

Houston, TX

Laura Wiginton, a mental-health clinic in Houston, specializes in ketamine-assisted psychotherapy for treatment-resistant depression, anxiety, and PTSD. The practice frames ketamine therapy within a …

  • Ketamine Therapy
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Regulatory context

A note on Texas's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • HB 1802 / Psilocybin and MDMA Research (2021)
    Required Texas Health and Human Services Commission to study psilocybin and MDMA for PTSD treatment in veterans; report completed.
  • Texas Ibogaine Initiative (HB 3717, 2025 pending)
    Would allocate $50 million for FDA-regulated ibogaine clinical trials, potentially the largest state psychedelic research investment in US history.
  • Texas Controlled Substances Act
    Mirrors federal scheduling.

Texas enforces federal scheduling. The Texas Medical Board oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Texas PMP requires controlled substance reporting. Texas has seen rapid ketamine clinic growth in Austin, Dallas, and Houston markets with corresponding enforcement attention on compounding and telehealth practices.

Ketamine Therapy in Houston, answered.

In Houston, a single IV ketamine infusion typically runs 500 to 900 dollars, with a full 6 session induction protocol at 3,000 to 5,400. Premium clinics on the higher end, more affordable providers on the lower end. Intramuscular ketamine often costs less, around 250 to 500 per session. Compounded ketamine lozenges via telehealth run 250 to 500 per month. Spravato (esketamine) is frequently covered by insurance for treatment resistant depression; out of pocket list price is roughly 600 to 900 per treatment session, with most patients paying a copay.

Ketamine is a Schedule III controlled substance and has been FDA approved as an anesthetic since 1970. Spravato (esketamine), a derivative nasal spray, is FDA approved for treatment resistant depression under a REMS program requiring in clinic administration and post dose monitoring. IV, intramuscular, and compounded oral ketamine for depression, PTSD, and chronic pain are used off label with Emerging to Strong evidence depending on indication. Off label prescribing is legal for DEA registered providers but must follow state and federal controlled substance rules.

Houston ketamine is delivered by MDs and DOs (typically psychiatrists, anesthesiologists, emergency medicine, or pain specialists) holding a DEA registration and Texas controlled substance authority. Nurse practitioners and physician assistants may prescribe or administer depending on Texas scope of practice and supervisory rules. Spravato requires a REMS certified clinic and certified prescriber. Verify the provider's DEA registration, board certification, and whether a monitoring clinician is present during infusions.

Yes, with caveats. Mindbloom, Joyous, Innerwell, and similar platforms prescribe compounded ketamine lozenges to Texas residents through telehealth, subject to the Ryan Haight Act and DEA special registration rules currently in effect. These programs pair at home dosing with virtual integration support and cost roughly 250 to 500 per month. In clinic IV and intramuscular ketamine remain the standard for treatment resistant depression and PTSD and cannot be delivered via telehealth. Spravato always requires in clinic REMS administration.

Verify DEA registration on the DEA Office of Diversion Control registrant lookup and Texas medical board license status. Confirm board certification in psychiatry, anesthesiology, emergency medicine, or pain medicine. Ask about the monitoring protocol during infusion (vitals, continuous clinician presence), integration therapy options, and the clinic's crisis and safety plan. Check whether the clinic is Spravato REMS certified if that is your treatment path. Be cautious of providers who skip screening, push large prepaid packages, or offer take home IV ketamine.

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