For most adults the best NAD+ supplement is a third-party tested NR or NMN product at 250 to 1,000 mg a day, since both raise blood NAD+ in human trials. Here is how NMN, NR, niacin and IV NAD+ compare on evidence, dosing, safety and cost.
Everything you need to know about NAD+ IV therapy — how it works, what it costs, what the evidence actually shows, how it compares to supplements, side effects, and how to choose a provider. Updated 2026.
NMN is the direct precursor to NAD+ and NR is one step further back, and both raise blood NAD+ in human trials. NR has more published trials, NMN has a strong 2021 Science result, and no large study has compared them head to head.
NAD+ IV therapy for anti-aging infuses 250 to 1,000 mg of NAD+ over 2 to 4 hours to restore levels that fall with age. The biology is well studied, but no randomized trial shows IV NAD+ slows aging in people, and it is not FDA approved.
At a Glance Session duration: 2-4 hours depending on dose and your tolerance (slower drip = fewer side effects). Common doses: 250 mg (introductory), 500 mg (standard), 750 mg+ (high-dose/therapeutic). Typical cost: $250-$1,000+ per session depending on dose and location. Side effects during infusion are common but manageable – nausea, chest tightness, and cramping usually…
NR and NMN are NAD+ precursors that cells convert into NAD+, while oral NAD+ is mostly broken down in the gut. NR has the most human trial data, and no trial has shown NMN or NR to be clearly better.
