Rapamycin (sirolimus) is the only drug shown to reliably extend lifespan in animals, but human longevity evidence is still early and unproven. Here is what the science shows in 2026, plus the real risks.
Klotho is a protein and hormone that helps regulate phosphate and vitamin D and is a leading longevity research target. Here is what the science actually shows, and what it does not.
Senolytics target the zombie senescent cells that drive aging and inflammation. Strong in mice, early in humans. Here is what the evidence actually shows.
Therapeutic plasma exchange (plasmapheresis) is proven first-line care for autoimmune and neurological diseases. Its anti-aging use is experimental. Here is what the evidence shows.
Methylene blue is an FDA-approved drug whose only established benefit is treating methemoglobinemia. Arsenic is a grade issue: pharmaceutical grade is tested for heavy metals, aquarium and lab grades are not.
Dasatinib plus quercetin (D+Q) is the first senolytic combination, pairing the leukemia drug dasatinib with the flavonoid quercetin to clear senescent cells. It extended survival in old mice, but human evidence is limited to small pilots and one randomized trial that missed its primary endpoint.
Fisetin is a strawberry flavonoid that cleared senescent cells and extended lifespan in aged mice. Human evidence is early: Mayo Clinic's AFFIRM trials are testing a two-day high dose, and no human dose is validated.
An honest evidence review of urolithin A, the gut-microbiome mitophagy activator. What the randomized human trials show for muscle strength and mitochondrial health, the 500 to 1,000 mg doses used, safety, and what remains unproven.
Normobaric oxygen is oxygen breathed at normal sea level pressure, while hyperbaric oxygen therapy is near 100% oxygen in a chamber at 2 to 3 ATA. Pressure lifts plasma oxygen from about 1.5 to 6 mL per 100 mL of blood.
For most healthy women under 60 or within 10 years of menopause, hormone therapy is the most effective treatment for hot flashes, and its benefits generally outweigh its risks. Here is what the WHI showed, the timing hypothesis, and who HRT is for.
Semaglutide and tirzepatide can help women with PCOS and excess weight lose weight and improve insulin resistance, with early signs of more regular cycles. Neither is FDA approved for PCOS, and both need a clear plan around pregnancy.
Tesamorelin is the one growth-hormone peptide with real clinical evidence for reducing deep belly fat. A clear, evidence-based look at how it works, the approved use, off-label interest, side effects, and safety.
