Rapamycin (sirolimus) is the only drug shown to reliably extend lifespan in animals, but human longevity evidence is still early and unproven. Here is what the science shows in 2026, plus the real risks.
Klotho is a protein and hormone that helps regulate phosphate and vitamin D and is a leading longevity research target. Here is what the science actually shows, and what it does not.
Senolytics target the zombie senescent cells that drive aging and inflammation. Strong in mice, early in humans. Here is what the evidence actually shows.
Therapeutic plasma exchange (plasmapheresis) is proven first-line care for autoimmune and neurological diseases. Its anti-aging use is experimental. Here is what the evidence shows.
Methylene blue is an FDA-approved drug whose only established benefit is treating methemoglobinemia. Arsenic is a grade issue: pharmaceutical grade is tested for heavy metals, aquarium and lab grades are not.
Dasatinib plus quercetin (D+Q) is the first senolytic combination, pairing the leukemia drug dasatinib with the flavonoid quercetin to clear senescent cells. It extended survival in old mice, but human evidence is limited to small pilots and one randomized trial that missed its primary endpoint.
Fisetin is a strawberry flavonoid that cleared senescent cells and extended lifespan in aged mice. Human evidence is early: Mayo Clinic's AFFIRM trials are testing a two-day high dose, and no human dose is validated.
An honest evidence review of urolithin A, the gut-microbiome mitophagy activator. What the randomized human trials show for muscle strength and mitochondrial health, the 500 to 1,000 mg doses used, safety, and what remains unproven.
Oral collagen is partly absorbed as small peptides and improves skin hydration and elasticity in randomized trials, but the studies are small and often industry funded. Few longevity supplements have human outcome data, and CoQ10 in heart failure has the strongest.
At a Glance Next step: Read the NAD IV therapy guide, then find vetted clinics that list NAD. NAD IV therapy guide · Find vetted NAD IV clinics NAD+ levels decline substantially with age – this decline is now considered a hallmark of the aging process. The mechanism is well-established: NAD+ fuels sirtuins, PARPs, and…
IV NAD+ gives 100% bioavailability at $500-$1,500 a session, while oral NR and NMN raise blood NAD+ by 40-90% for $40-$100 a month. Here is which form fits which situation.
GHK-Cu is a natural copper peptide that changes the activity of more than 4,000 genes in lab studies, with its best human evidence in small topical skin trials. Here is what the research shows for skin, hair and wound healing, plus dosing, safety and its 2026 FDA status.
