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Read the Ketamine Therapy guide for the educational context behind this treatment category.
Colorado Springs, CO
Adults in Colorado Springs researching ketamine therapy for treatment resistant depression need to confirm where treatment happens, what a first visit involves, and who oversees care. Compare the local listings for the treatment format offered and coordination with your existing mental health clinician.
Local ketamine services include offices around East Woodmen Road near Briargate, along Union Boulevard, and on Sinton Road near I-25. For travel from Monument, Fountain, or Pueblo, compare the treatment address with your I-25 route; from the east side, consider connections from Powers Boulevard. A Colorado Springs mailing address does not always mean an in-person treatment site, so confirm exactly where sessions take place. Arrange a ride home and allow time for observation before discharge.
Treatment resistant depression generally means depression that has not responded adequately to antidepressant trials. Local options include intravenous ketamine administered by clinical staff in a monitored medical office and esketamine nasal spray self-administered under direct observation in a certified healthcare setting; ask which is offered. A first visit covers psychiatric and medical history, medications, blood pressure, substance use, and previous medication and therapy trials. Later visits track mood, side effects, and function, with dosing and spacing set by the prescribing clinician based on response. IV ketamine for depression is off-label and usually cash pay; esketamine has FDA approval for certain depression cases.
Before booking, ask who prescribes and administers treatment, what their licensure and supervision involve, where the medication comes from, and how risks and side effects are disclosed in writing. Ask what happens if symptoms do not improve and request a written quote separating evaluation, medication, administration, monitoring, psychotherapy, and follow up visits.
Organic listing order on Regenerated.com is never sold. Featured placements are clearly labeled and capped. A Verified badge reflects credential checks on a provider, not how much they paid. Regenerated.com is free for patients, and appearing in this directory is not an endorsement of any clinic or treatment.
The national ketamine therapy hub covers how treatment works and the broader evidence, including uncertainty about lasting benefit from IV treatment. For more on how this directory works, read How to read a Regenerated city hub and Featured vs Verified vs organic.
Regulatory context
Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.
Colorado Healing Centers began licensing and operating in late 2024 and early 2025. The Colorado Department of Regulatory Agencies (DORA) Natural Medicine Division oversees facilitator licensure, healing center operations, testing, and track-and-trace. Federal law still classifies psilocybin as Schedule I, so DEA enforcement risk remains theoretical. The Colorado Medical Board regulates ketamine prescribing. Ryan Haight Act applies to telehealth ketamine.
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