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20 Best Ketamine Therapy Clinics in Indiana

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

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Read the Ketamine Therapy guide: evidence, costs and questions to ask

Indiana

Ketamine Therapy clinics in Indiana

Ketamine therapy clinics in Indiana are concentrated in and around Indianapolis, with additional locations in the surrounding suburbs. Fort Wayne, Evansville and South Bend also have treatment options, giving patients in the northeastern, southwestern and northern parts of the state regional alternatives to driving to the capital. Rural stretches of the state, including much of southern and western Indiana, have limited or no local access, and patients there should expect a drive of an hour or more. Some residents near the Ohio, Kentucky or Illinois borders may find it practical to compare options across state lines, though this page covers Indiana listings only.

Indiana has no ketamine specific statute; it relies on the general federal and professional rules that already govern prescribing and administering controlled substances, so the main question is who is licensed to prescribe, administer and supervise it. A physician or physician assistant typically orders and oversees treatment, while a nurse may administer it under that supervision, consistent with Indiana's scope of practice rules. Treatment is usually delivered in a physician's office or a dedicated infusion suite rather than a spa style setting.

You can check a prescriber's standing through the Indiana Professional Licensing Agency, which administers the Medical Licensing Board of Indiana for physicians and physician assistants. Nurses can be verified through the Indiana State Board of Nursing. A clean license record confirms someone is currently authorized to practice in Indiana and shows any public disciplinary history; it does not tell you how much ketamine experience that person has or predict an outcome.

Before booking anywhere in Indiana, ask who evaluates you, who is physically present during treatment, and what credential that person holds. Ask exactly what is being administered, intravenous ketamine, nasal esketamine or a compounded nasal formulation, and where it comes from. Ask how risks and side effects are disclosed in writing, what the plan is if treatment does not help, and request a quote that itemizes evaluation, medication, monitoring and follow-up.

Listing order on this page is not paid ranking. Featured slots are labeled and capped, and a Verified label reflects credential checks rather than how much a clinic paid. Regenerated.com is free for patients to use, and appearing in this directory is not an endorsement of any clinic. The national ketamine therapy hub covers the mechanism and the evidence. Read How to read a Regenerated city hub and Featured vs Verified vs organic.

20 Clinics, showing page 2 of 2

NWI Integrative Health & Wellness
(91) Physician status unknown

NWI Integrative Health & Wellness

Winfield, IN

NWI Integrative Health & Wellness, in Crown Point, specializes in peptide therapy, hormone replacement therapy, and testosterone replacement therapy alongside IV nutrient infusions and ketamine thera…

  • Vitamin IV Therapy
  • Ozone Therapy
  • IV Therapy
  • Hyperbaric Oxygen Therapy (HBOT)
  • Oxygen Therapy
Accentus Mental Health
(28) Physician status unknown

Accentus Mental Health

Indianapolis, IN

Accentus Mental Health, a veteran-owned clinic serving greater Indianapolis, specializes in ketamine therapy and esketamine (Spravato®) for treatment-resistant depression, anxiety, and obsessive-comp…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
Zionsville Ketamine
(10) Physician reported in record

Zionsville Ketamine

Zionsville, IN

Zionsville Ketamine, located in Zionsville, Indiana, specializes in ketamine therapy for treatment-resistant depression, anxiety, and PTSD. The clinic offers both intramuscular ketamine and intranasa…

  • Ketamine Therapy
  • NAD IV Therapy
Ketaklarity
(8) Physician status unknown

Ketaklarity

Greencastle, IN

Ketaklarity, a ketamine-therapy clinic in Greencastle, Indiana, offers IV ketamine infusions for treatment-resistant depression, anxiety, PTSD, and related mood and neurological conditions. The clini…

  • IV Therapy
  • Ketamine Therapy
  • Migraine Treatment
Indiana Advanced Psychiatry
(19) Physician status unknown

Indiana Advanced Psychiatry

Fort Wayne, IN

Indiana Advanced Psychiatry, a ketamine-therapy clinic in Fort Wayne, offers ketamine-assisted treatment for mental-health conditions alongside IV therapy and hormone replacement therapy. The practic…

  • IV Therapy
  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Hormone Replacement Therapy (HRT)
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Regulatory context

A note on Indiana's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • SB 139 / Psilocybin Research (2024)
    Authorized clinical research on psilocybin for treatment-resistant mental health conditions at Indiana universities; no therapeutic access framework.
  • Indiana Controlled Substances Act
    Mirrors federal scheduling.

Indiana enforces federal scheduling. The Indiana Medical Licensing Board oversees prescriber conduct. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth rules. Indiana INSPECT PDMP requires controlled substance reporting.

Sources: dea.gov · in.gov · in.gov · iga.in.gov

Ketamine Therapy in , answered.

Ketamine therapy describes giving ketamine, usually by IV infusion, nasal spray, or a compounded nasal formulation, to treat certain mental health conditions. In Indiana, treatment is typically delivered in a physician's office or infusion suite under the supervision of a physician or physician assistant. Esketamine, the nasal form with FDA approval for depression, is distinct from off label IV ketamine, and a clinic should be clear about which one it offers.

Most Indiana clinics offering ketamine therapy are located in or near Indianapolis, with additional options in Fort Wayne, Evansville and South Bend. Patients outside these metros, including much of rural southern and western Indiana, generally need to travel to reach a clinic. This statewide listing shows where current options are, but call ahead to confirm formulation, scheduling and whether a location is accepting new evaluations.

Cost depends on the formulation used, how much monitoring and staffing a session requires, and whether psychotherapy is bundled in. IV ketamine for depression is usually billed as cash pay, while esketamine may be covered by insurance when a plan's specific criteria are met. Ask any clinic for a written quote that separates evaluation, medication, monitoring and follow-up, since this page does not publish average prices.

Indiana does not have a law written specifically for ketamine; it relies on the general federal and professional rules that already govern prescribing and administering controlled substances. In practice this means a physician or physician assistant typically orders and supervises treatment, while a nurse may administer it under that oversight, following Indiana's standard scope of practice rules for medical and nursing licenses.

Physicians and physician assistants can be verified through the Indiana Professional Licensing Agency, which administers the Medical Licensing Board of Indiana, and nurses can be checked through the Indiana State Board of Nursing. Both let you confirm a license is active and review public disciplinary history. Neither one tells you how experienced a provider is with ketamine specifically, so ask about that directly.

Ketamine therapy is generally considered for adults with treatment resistant depression or certain other conditions who have already tried standard options without enough relief. People with uncontrolled high blood pressure, certain heart conditions, active substance misuse, or psychosis are often told to wait or seek a different approach after evaluation. A proper screening by a qualified provider, not a brief phone call, is what should decide this.

Ketamine therapy is most studied for treatment resistant depression, and esketamine has approval for that specific use. Use for anxiety, PTSD, bipolar depression and addiction is explored in smaller studies and off label practice, and the evidence for lasting benefit in those areas is still limited. Ask any Indiana provider what the proposed use is based on and how improvement will be measured.

This page covers ketamine therapy clinics across Indiana rather than one city, so it works for comparing regions before narrowing to a specific metro's city page or the national ketamine therapy hub for background on the treatment itself. Unlike a general search, Regenerated.com does not sell organic order, labels and caps Featured slots, and uses Verified to mean credential checks rather than ad spend.

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