53 Ketamine Therapy Clinics in New York City, New York (2026)

Ketamine Therapy clinics in New York City

Looking for ketamine therapy for depression in New York City means comparing the medication offered, psychiatric oversight, and the trip home. Options include medical offices in Midtown East, Chelsea, and the Upper East Side, with Brooklyn choices near Court Street in Brooklyn Heights and in Williamsburg. Being near a subway line does not settle discharge arrangements. Confirm the treatment address, arrange an adult escort, and ask about travel restrictions before planning a ride home.

Local services include IV infusions in medical offices or infusion suites, supervised nasal esketamine, and ketamine paired with psychotherapy, each with different prescribing, monitoring, and insurance requirements. IV ketamine for depression is an off-label use, meaning it is not FDA approved for that condition; nasal esketamine has specific approved depression indications. Evidence supports benefit for some people with treatment-resistant depression, while lasting benefit and long-term use remain less certain.

Some New York City practices also see patients asking about ketamine therapy for PTSD rather than depression alone. IV ketamine for PTSD is off-label, and the research is earlier stage and thinner than for treatment-resistant depression; nasal esketamine's approval covers depression, not PTSD. Ask whether the office coordinates with a trauma-focused therapist, since these sessions are usually paired with psychotherapy.

An initial assessment should review your depression history, any post-traumatic stress symptoms, previous treatments, medications, physical health, and substance use. Ask who prescribes, who administers the medication, who monitors recovery, and how the team coordinates with your existing clinician. Follow-up should track symptoms and side effects, with a clear point for reconsidering treatment if it does not help.

Before booking, request the exact formulation, its supplier, and written information about risks and side effects. Ask what the quote includes and what is billed separately, including psychiatric assessment, medication, monitoring, psychotherapy, and follow-up. IV treatment for depression is often cash pay, so confirm coverage with your insurer directly rather than relying on general statements.

Regenerated.com is free for patients, and organic listing order cannot be bought. Featured placements are labeled and capped; Verified indicates credential checks, not spending. Inclusion in this directory is not an endorsement of a provider.

See the national ketamine therapy hub for how the treatment works and the broader evidence. For help comparing this local list, read How to read a Regenerated city hub and Featured vs Verified vs organic.

A note on New York's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

S 3520 / Psilocybin Assisted Therapy (2023)
Proposed a state psilocybin therapy framework; pending.
A 114 / Psychedelic Decriminalization (2023)
Proposed decriminalization of possession and use of psilocybin, MDMA, DMT, mescaline, and ibogaine; pending.
New York Public Health Law Article 33
Mirrors federal scheduling and governs controlled substance prescribing; requires NY-specific practitioner registration.

New York enforces federal and state scheduling. The New York State Bureau of Narcotic Enforcement (BNE) requires practitioners to obtain a New York State Controlled Substance License in addition to federal DEA. The Office of Professional Medical Conduct oversees prescriber discipline. DEA enforcement on ketamine clinics focuses on diversion and Ryan Haight Act telehealth compliance. New York PMP (I-STOP) requires electronic prescribing for controlled substances.

Ketamine Therapy in New York City, answered.

Ketamine therapy uses a prescription anesthetic at clinician-selected doses to address depression, usually after standard care has not helped enough. New York City services may offer IV ketamine, ketamine-assisted psychotherapy, or the related medication nasal esketamine. These are distinct approaches. Ask which medication and route the office offers, whether psychotherapy is included, and who takes responsibility for your ongoing depression care.

Costs depend on the formulation, medical staffing, monitoring, and whether psychotherapy is included. IV ketamine for depression is often cash pay; nasal esketamine may qualify for insurance coverage subject to eligibility, network rules, and prior authorization. Request an itemized quote covering evaluation, medication, administration, recovery monitoring, and follow-up. This page does not publish an average because different services and insurance arrangements make a single figure misleading.

Adults with depression that has persisted despite appropriate treatment may be considered after a psychiatric and medical evaluation. Uncontrolled blood pressure, significant cardiovascular illness, pregnancy, active psychosis, or substance misuse concerns may lead a clinician to defer treatment or recommend another approach. A history of mania needs careful assessment. Bring prior treatment records so the New York City prescriber can evaluate suitability rather than relying on symptoms alone.

After screening and consent, clinical staff administer ketamine through an IV and monitor your vital signs, alertness, and recovery under medical supervision. An initial treatment phase should include scheduled reviews of mood, daily functioning, and adverse effects before deciding whether to continue or change the plan. Ask how between-visit concerns are handled and how follow-up coordinates with your psychiatrist or therapist. Arrange an adult escort home and follow the office's driving restrictions.

Possible effects include nausea, dizziness, sedation, increased blood pressure, and dissociation, a feeling of detachment from yourself or your surroundings. Breathing problems and misuse are serious concerns; repeated exposure also raises questions about urinary symptoms and longer-term effects. Ask how staff monitor you, respond to complications, and decide when you can leave. Written instructions should explain which symptoms need urgent attention and whom to contact after discharge.

Identify the licensed prescriber, the professional administering treatment, and the clinician responsible for monitoring and emergency care. Ask about experience treating depression and managing sedation-related complications. Check each professional's license and current registration through the New York State Education Department's Office of the Professions. For physicians and physician assistants, also check disciplinary actions through the state Department of Health's Office of Professional Medical Conduct. A directory badge does not replace these checks.

Research supports rapid symptom relief for some adults with treatment-resistant depression, but others do not respond, and improvement may fade. IV ketamine remains off-label for depression, while nasal esketamine has specific FDA-approved depression uses. Evidence is less established for many other advertised uses and for long-term repeated ketamine treatment. Ask the provider how they will measure meaningful improvement and what alternatives they will discuss if benefits are absent or short-lived.

Use this city page to compare locations, treatment formats, and practical access; the national hub explains mechanisms and evidence. Unlike a general web search, this directory puts local listings within a stated placement policy. Organic order is not sold, Featured slots are labeled and capped, and Verified means credential checks rather than spending. Regenerated.com is free for patients, and inclusion is not an endorsement. Confirm services, supervision, and availability directly before booking.

53 Ketamine Therapy Clinics in New York City, New York

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

Ketamine Therapy clinics in New York City

53 Clinics, showing page 4 of 4

Adorno Counseling

Village TMS

Hyperbaric Medical Solutions

Harmonic Thread Psychotherapy

Brooklyn Integrative Psychiatry

Unitas / St. Mark's Place Institute for Mental Health

Amanda Itzkoff

Psyberspace Center for Psychedelic Therapy

A note on New York's ketamine therapy rules.

Ketamine Therapy in New York City, answered.

Ketamine Therapy in nearby Cities

Other Treatments available in New York City

53 Ketamine Therapy Clinics in New York City, New York

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

Ketamine Therapy clinics in New York City

53 Clinics, showing page 4 of 4

A note on New York's ketamine therapy rules.

Ketamine Therapy in New York City, answered.

What is ketamine therapy for depression in New York City?

How much is ketamine therapy in New York City, and does insurance cover it?

Who is a good candidate for ketamine therapy in New York City?

What does intravenous ketamine therapy involve at a New York City office?

What side effects can ketamine therapy cause?

What credentials should ketamine therapy providers in New York City have?

Does ketamine therapy for depression work when antidepressants have not helped?

How can I compare ketamine therapy providers in New York City?

Ketamine Therapy in nearby Cities

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