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13 Best Ozone Therapy Clinics in San Diego, California

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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San Diego, CA

Ozone Therapy clinics in San Diego

Ozone Therapy in San Diego, CA

intro

San Diego, California has a visible integrative and functional medicine scene, and clinics in the area advertise ozone therapy as part of their services. Ozone is a three-oxygen molecule that practitioners deliver through several delivery methods, including major autohemotherapy (MAH), minor autohemotherapy (MinorAH), prolozone joint injections, rectal or vaginal insufflation, ozonated saline, and higher-dose protocols such as 10-pass ozone. The proposed mechanism is oxidative hormesis, a brief and controlled oxidative challenge that is theorised to upregulate endogenous antioxidant defences, modulate immune signalling pathways, and improve tissue oxygen utilisation at the mitochondrial level. It is critical to be clear with patients up front: ozone therapy is NOT FDA-approved for any medical use. The FDA issued a formal declaration in 1976 stating that ozone is a toxic gas with no known useful medical application, and that position has not been revised in the decades since. Clinics listed here offer ozone under physician clinical judgement, not under an approved indication, so patients should evaluate evidence quality, informed consent language, and provider credentials carefully before booking a session or committing to a package.

13 Clinics

MD on staff

Saffron & Sage

San Diego, CA

Saffron & Sage, an integrative clinic in San Diego, specializes in peptide therapy and hormone optimization for men and women, alongside platelet-rich plasma injections and IV therapy. The practice c…

  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy
  • IV Therapy
  • Arthritis Treatment
MD on staff

RestorMedicine

San Diego, CA

RestorMedicine, a functional and integrative-medicine clinic in San Diego, offers ozone therapy (including 10-pass protocols), IV nutrient therapy, and chelation therapy alongside peptide therapy wit…

  • Ozone Therapy
  • IV Therapy
  • Neurofeedback Therapy
  • IV Hydration
  • Chelation Therapy

George Georgaklis DDS

San Diego, CA

George Georgaklis DDS, a regenerative dentistry practice in San Diego, offers ozone-supported procedures alongside conventional restorative and TMJ treatment. The practice emphasizes biocompatible ap…

  • Ozone Therapy
  • Laser Therapy (LLLT)
  • TMJ Treatment
MD on staff

LIVV Natural & Med Spa

San Diego, CA

LIVV Natural & Med Spa, located in San Diego, offers a range of regenerative and supportive-medicine modalities including IV nutrient therapy, NAD+ infusions, peptide protocols, and platelet-rich pla…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy
  • IV Therapy
MD on staff

Katalyst Wellness

San Diego, CA

Katalyst Wellness, a peptide and hormone optimization clinic in San Diego, specializes in bioidentical hormone replacement therapy for men and women, alongside peptide protocols and regenerative moda…

  • PRP Therapy
  • Ozone Therapy
  • IV Therapy
  • Arthritis Treatment
  • Peptide Therapy
MD on staff

Limphocite

San Diego, CA

Limphocite, located in San Diego, specializes in peptide therapy and hormone optimization alongside regenerative-medicine and immunotherapy protocols. The clinic offers ozone therapy, lymphatic-drain…

  • Ozone Therapy
  • Multiple Sclerosis (MS) Treatment
  • Arthritis Treatment
  • Lyme Disease Treatment
  • Peptide Therapy

Brighton Dental

San Diego, CA

Brighton Dental, a regenerative dentistry practice in San Diego, specializes in biological and restorative dental care using advanced modalities including ozone treatment, platelet-rich plasma therap…

  • PRP Therapy
  • Ozone Therapy
  • Laser Therapy (LLLT)

Joy Wellness Partners (JWP)

San Diego, CA

Joy Wellness Partners, an IV therapy and regenerative-medicine clinic in San Diego, offers a comprehensive suite of treatments centered on hormone optimization, cellular support, and pain management.…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Shockwave Therapy
  • Ozone Therapy
MD on staff

Pacific Regeneration

San Diego, CA

Pacific Regeneration, a regenerative medicine clinic in San Diego, offers stem-cell therapy, platelet-rich plasma injections, and ozone therapy for musculoskeletal pain, sports injuries, and chronic …

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy
MD on staff

LotusRain Naturopathic Clinic

San Diego, CA

LotusRain Naturopathic Clinic, a naturopathic medicine and IV therapy practice in San Diego, specializes in intravenous nutrient protocols and regenerative modalities for chronic metabolic conditions…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy
  • IV Therapy

Livewellmd

San Diego, CA

Livewellmd, a regenerative medicine clinic in San Diego, offers stem-cell therapy, platelet-rich plasma injections, and peptide protocols alongside IV nutrient therapy and ozone therapy. Treatment pl…

  • Stem Cell Therapy
  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • Ozone Therapy

Bioadvanced Medical Center

San Diego, CA

Bioadvanced Medical Center in San Jose offers colon hydrotherapy alongside platelet-rich plasma injections, combining digestive support with regenerative orthobiologic treatment. The clinic positions…

  • PRP Therapy
  • Colon Hydrotherapy
  • Ozone Therapy
  • IV Therapy
  • Red Light Therapy
MD on staff

SD PRP Clinic

San Diego, CA

SD PRP Clinic, a regenerative medicine clinic in San Diego, offers a broad range of cell-based therapies, orthobiologics, and supportive modalities. The clinic provides platelet-rich plasma therapy f…

  • PRP Therapy
  • Ozone Therapy
  • IV Therapy
  • Hyperbaric Oxygen Therapy (HBOT)
  • Acne Treatment
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Regulatory context

A note on California's ozone therapy rules.

The "other" category is a catchall for regenerative wellness modalities with inconsistent federal oversight. Red light therapy devices (photobiomodulation) have narrow FDA 510(k) clearances for acne, muscle pain, and wound healing, not systemic regeneration. Whole-body cryotherapy is NOT FDA-approved for any medical indication and received an FDA safety communication in July 2016 warning of asphyxiation, frostbite, and burn risks. Ozone therapy is NOT FDA-approved for any medical use and the FDA has stated ozone is a toxic gas with no known useful medical application. Condition-specific regenerative offerings (hair restoration with minoxidil or finasteride, ED care beyond PDE5 inhibitors and shockwave) have varying approval depending on route and drug source.

  • California Medical Practice Act (Bus. & Prof. Code §§ 2000-2529)
    Defines medical practice and corporate practice of medicine prohibitions strictly enforced against lay-owned medical spas.
  • California Business & Professions Code §§ 2051-2052
    Prohibits unlicensed practice of medicine and aiding and abetting by non-physician owners.
  • Board of Registered Nursing Standardized Procedures (CCR Title 16 § 1474)
    Requires physician-developed standardized procedures for RNs performing cosmetic and wellness injections or laser work.

California is among the strictest enforcement states. The Medical Board of California has issued public advisories and taken disciplinary action against medical spas for corporate practice of medicine violations, unsupervised RN injections, and false advertising of unapproved therapies. Ozone therapy is heavily scrutinized and clinics making cancer or infection treatment claims risk board discipline and Attorney General consumer protection action. The California Department of Public Health and local health departments also investigate facility and infection control issues at wellness clinics.

Ozone Therapy in San Diego, answered.

No. Ozone therapy is NOT FDA-approved for any medical use. The FDA issued a 1976 declaration stating ozone is a toxic gas with no known useful medical application, and that position has not changed. Clinics that offer ozone do so under physician clinical judgement, not under an approved indication. Many marketing claims for ozone are unsupported by high-quality clinical evidence, so any informed decision about booking a session should start with that clear disclosure.

Pricing in San Diego typically runs $150 to $300 per session for standard major autohemotherapy (MAH), with prolozone joint injections, insufflation, and MinorAH often priced similarly or slightly lower. Higher-dose 10-pass ozone is considerably more expensive, usually $500 to $800 per session, with packages pushing totals into the thousands. Package pricing can lower the per-session rate but raises total spend. Remember that ozone is NOT FDA-approved, is not covered by insurance, and out-of-pocket cost is the norm.

Integrative practitioners commonly claim benefits for immune support, chronic infections such as Lyme disease and herpes, systemic inflammation, chronic fatigue, autoimmune conditions, and musculoskeletal pain using prolozone for joints and discs. The quality of clinical evidence supporting these claims is low, studies are often small or uncontrolled, and ozone therapy is NOT FDA-approved for any of these indications. Treat strong claims with caution.

In California, ozone therapy is most commonly delivered by MDs and DOs practising integrative or functional medicine, because naturopathic scope is either limited or unlicensed. Chiropractors generally cannot administer intravenous ozone, and scope varies by state medical and naturopathic board positions. Regardless of license type, verify active state licensure before any appointment, and remember that ozone therapy is NOT FDA-approved and is offered under physician clinical judgement rather than any approved indication.

Verify that the lead clinician holds an active state license, ask for written informed consent that clearly states ozone is NOT FDA-approved, and look for realistic evidence framing rather than cure claims. Avoid clinics that promise to cure cancer, autoimmune disease, or chronic infection. Membership in groups such as the AAOT is a peer-community signal, not an FDA credential, and should never substitute for verifying licensure and reading consent forms.

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