420 Best Lyme Disease Treatment Clinics in the US

This is the national page for Lyme disease treatment on Regenerated.com, listing clinics across the United States that record care for Lyme disease, also called Lyme borreliosis, and for symptoms that persist after it. Lyme disease is a bacterial infection caused mainly by Borrelia burgdorferi and spread by the bite of infected blacklegged ticks, Ixodes scapularis in the East and Ixodes pacificus on the West Coast. Standard treatment is a course of oral antibiotics such as doxycycline, amoxicillin or cefuroxime axetil, with IV ceftriaxone used for some neurologic or cardiac cases. Care is delivered by primary care physicians, infectious disease specialists, rheumatologists and neurologists, and also by integrative, functional and naturopathic clinicians who treat patients with long running symptoms. Patients often compare it with care for chronic fatigue syndrome, fibromyalgia, mold related illness and tick borne coinfections such as babesiosis and anaplasmosis.

The evidence is strongest for early antibiotic treatment. Guidelines published in 2020 by the Infectious Diseases Society of America, the American Academy of Neurology and the American College of Rheumatology support short antibiotic courses for early Lyme disease, Lyme arthritis, Lyme carditis and neurologic Lyme disease, and the antibiotics used are long established, FDA approved medicines. A minority of treated patients develop post treatment Lyme disease syndrome, with fatigue, pain or cognitive problems lasting months. Randomized trials of prolonged antibiotics for persistent symptoms, including the study led by Mark Klempner and the PLEASE trial in the Netherlands, did not show lasting benefit over placebo, and long courses carry real risks. The term chronic Lyme disease is contested, and some clinicians follow the broader approach of the International Lyme and Associated Diseases Society instead. Ozone, hyperbaric oxygen, IV vitamin drips, herbal protocols and similar integrative options are not approved for Lyme disease, evidence for them is thin, and they are usually cash pay.

A typical candidate has a confirmed or strongly suspected Lyme diagnosis, a known tick exposure, a bullseye rash called erythema migrans, positive two tier blood testing, or symptoms that remain after standard treatment. A new rash, facial palsy, chest pain, palpitations or fainting after a tick bite needs prompt medical review rather than a wellness booking. People who are pregnant, young children, and patients with heart symptoms usually need a physician led plan, and anyone offered long term antibiotics or IV lines should ask for a second opinion first.

Supply is spread nationwide and sits in several kinds of settings: primary care and infectious disease practices, hospital and university programs, integrative and functional medicine clinics, infusion suites and wellness studios. Reported Lyme cases concentrate in the Northeast, the mid Atlantic and the upper Midwest, especially Wisconsin and Minnesota, with fewer in northern California. Listings for longer term or integrative Lyme care also appear outside those regions, including the Southeast, Southwest and Mountain West. Many patients across the country travel for an initial evaluation and then continue follow up by telehealth or with a local physician.

Before booking anywhere, ask who holds the license and who supervises each treatment. Ask exactly what is administered, in what dose and by what route, where it comes from, whether it is compounded, and whether its use for Lyme disease follows guidelines or is off label. Ask which lab runs any testing and whether it uses FDA cleared tests. Request written disclosure of risks, an itemized quote covering visits, labs, medicines and infusions, and a clear plan for follow up and for stopping a treatment that does not help.

This national list is not for sale. Organic order is never paid ranking, Featured slots are labeled and capped, and Verified means the clinic completed credential checks, not that it spent money. Regenerated.com is free for patients, and inclusion in the directory is not an endorsement of any clinic or treatment. Use the state hubs below the list to build a shortlist of Lyme disease treatment providers closer to you, and read about Lyme disease as a condition for symptoms and testing.

For treatment options and evidence in more depth, read the Lyme disease treatment guide. Two short explainers cover how listings work here: How to read a Regenerated city hub and Featured vs Verified vs organic.