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3 Best Psychedelic Therapy Clinics in San Diego, California

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

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San Diego, CA

Psychedelic Therapy clinics in San Diego

Psychedelic-assisted therapy in San Diego sits mostly in the ketamine-assisted psychotherapy category, with some clinics also preparing for state-specific psilocybin frameworks. Psychiatric referrals for complex cases route through UC San Diego Health, Sharp HealthCare, and Scripps Health. Demand reflects a military, biotech, and longevity-focused population.

Ketamine-assisted psychotherapy has the strongest US evidence base among psychedelic modalities. Psilocybin is not FDA approved and is only legally accessible within research or specific state programs. MDMA therapy is investigational. Clinics in San Diego, California should be evaluated for therapist training, safety protocols, and honest evidence framing. California Medical Board scrutiny of stem cell and regenerative claims determines what can legally be offered.

With psychedelic therapy clinics on Regenerated.com in San Diego, patients can compare clinician training, integration support, and legal framework before booking.

3 Clinics

Velara Wellness

San Diego, CA

Velara Wellness, a ketamine and psychedelic-assisted therapy clinic in San Diego, offers Ketamine Infusion Therapy, Spravato (intranasal esketamine), and Transcranial Magnetic Stimulation for treatme…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Psychedelic Therapy
 MD on staff

Daydream MD

San Diego, CA

Daydream MD, a ketamine and psychedelic-assisted therapy clinic in San Diego, specializes in ketamine infusion and Spravato treatment for treatment-resistant depression and anxiety, alongside psyched…

  • IV Therapy
  • Ketamine Therapy
  • Psychedelic Therapy
  • Peptide Therapy
  • NAD IV Therapy
 MD on staff

Center for Natural Anxiety Relief

San Diego, CA

Center for Natural Anxiety Relief, in San Diego, combines neurofeedback and brain-mapping protocols with IV nutrient and NAD+ therapies to address anxiety, ADHD, autism spectrum disorder, and PTSD ac…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • IV Therapy
  • Neurofeedback Therapy
  • IV Hydration
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Regulatory context

A note on California's psychedelic therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • SB 803 (2023, vetoed) and SB 1012 (2024, stalled)
    Proposed regulated therapeutic access to psilocybin, MDMA, mescaline, and DMT; Governor Newsom vetoed SB 58 (2023) citing lack of treatment guidelines.
  • Local decriminalization resolutions
    Oakland (2019), Santa Cruz (2020), Arcata, San Francisco, and Berkeley have passed non-binding resolutions deprioritizing enforcement of natural psychedelics; no legal therapeutic framework.

California enforces federal DEA scheduling. The Medical Board of California investigates prescriber misconduct, including ketamine diversion and inadequate patient monitoring. Several high-profile California ketamine-related deaths (including Matthew Perry's 2023 overdose) have intensified board scrutiny of clinic practices. DEA enforcement targets compounding, diversion, and Ryan Haight Act telehealth compliance.

Sources: dea.gov · leginfo.legislature.ca.gov · mbc.ca.gov · pharmacy.ca.gov

Psychedelic Therapy in San Diego, answered.

In California, ketamine-assisted psychotherapy is the primary legal option. Ketamine is a Schedule III controlled substance prescribed off label for depression, anxiety, and PTSD. Psilocybin and MDMA are Schedule I federally and not legally available in California. Only Oregon (Measure 109) and Colorado (Proposition 122) currently operate regulated psilocybin programs.

In San Diego, ketamine-assisted psychotherapy typically runs 400 to 900 dollars per session, with full protocols of six sessions costing 2,500 to 6,000 dollars. IM injection sessions tend to be less expensive than IV infusions. Spravato (esketamine nasal spray) is FDA-approved for treatment-resistant depression and may be covered by insurance with prior authorization, though out-of-pocket copays vary. Integration therapy sessions are often billed separately at 150 to 300 dollars each.

Not as an FDA-approved treatment. In August 2024 the FDA issued a Complete Response Letter to Lykos Therapeutics (formerly MAPS PBC) for MDMA-assisted therapy for PTSD, citing concerns about trial design and data quality. MDMA remains Schedule I federally. Some expanded access and clinical trial pathways exist, but no San Diego clinic can legally prescribe MDMA outside of those frameworks. Lykos has stated it plans to resubmit following additional trial work.

Ketamine-assisted psychotherapy is used off-label for treatment-resistant depression, PTSD, anxiety, and suicidal ideation. Spravato (esketamine) carries FDA approval specifically for treatment-resistant depression and major depressive disorder with acute suicidal ideation or behavior. Evidence quality is strongest for depression, with multiple randomized trials supporting short-term benefit. San Diego clinics typically screen for cardiovascular conditions, psychotic disorders, and active substance use before starting treatment.

Verify the prescriber on the California medical board license lookup and NPI registry. Confirm the clinician has training in psychedelic-assisted therapy through MAPS, Fluence, Polaris, or a comparable program. Ask about screening protocols, emergency procedures, and whether a therapist is present during sessions. Check the FDA warning letter database. Avoid clinics promising guaranteed outcomes, pushing large prepaid packages, or operating outside of state licensure. Integration support should be part of any reputable protocol.

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