What does this directory page list?
Read the Psychedelic Therapy guide for the educational context behind this treatment category.
Colorado
Psychedelic Therapy clinics in Colorado
Guided psychedelic-assisted therapy in Colorado can mean two different services, and it helps to know which one you want before you compare listings. One is a supervised psilocybin session at a state-licensed healing center, led by a state-licensed facilitator under Colorado's natural medicine program, which adults can use without a prescription or a diagnosis. The other is ketamine-assisted treatment in a medical or mental health practice, where a prescriber evaluates you and clinical staff monitor the session. A facilitated psilocybin session is not medical treatment, psilocybin remains illegal under federal law, and a facilitator is not necessarily a licensed clinician, so ask whether a licensed therapist is involved if that matters to you.
Most of the supply sits along the Front Range. The Denver metro carries the largest share, with Boulder, Fort Collins and Colorado Springs adding more, and a few mountain resort communities have options of their own. The Western Slope, the San Luis Valley and the Eastern Plains have little or nothing, so people there should expect a long drive and possibly an overnight stay, since a session can take most of a day and you should not drive yourself home afterwards.
To check a provider, look up physicians and physician assistants with the Colorado Medical Board and nurses with the Colorado State Board of Nursing, both through the Department of Regulatory Agencies, whose online lookup also covers psychologists, counselors and social workers. Facilitators and healing centers hold separate natural medicine licenses, so ask for both and confirm them with the state program. A lookup shows whether a license is active and any public discipline. It does not tell you about skill, results or fit.
Before booking anywhere in the state, ask who leads and supervises the session and what their credentials are, exactly what is being given and where it comes from, how screening and risks are explained in writing, what happens if a session goes badly or does not help, and what a written quote itemizes. The state regulation summary on this page covers the formal rules.
Listing order here is not sold. Featured slots are labeled and capped, Verified means the clinic completed credential checks, and Regenerated.com is free for patients. Inclusion is not an endorsement. The national psychedelic therapy hub covers mechanisms and evidence. To compare entries, read How to read a Regenerated city hub and Featured vs Verified vs organic.
32 Clinics,
Heartmind Medicine
- Neurofeedback Therapy
- Ketamine Therapy
- Psychedelic Therapy
NeuroGrove Services
- Biofeedback Therapy
- Neurofeedback Therapy
- Ketamine Therapy
- Migraine Treatment
- Psychedelic Therapy
Wholeness Center
- Biofeedback Therapy
- Neurofeedback Therapy
- Ketamine Therapy
- Psychedelic Therapy
Shadid Integrative Psychiatry - Nicole Shadid M.D.
- Biofeedback Therapy
- Neurofeedback Therapy
- Ketamine Therapy
- Psychedelic Therapy
- Hormone Replacement Therapy (HRT)
Wild and Wonderful Life
- Ketamine Therapy
- Psychedelic Therapy
- Hormone Replacement Therapy (HRT)
Regulatory context
A note on Colorado's psychedelic therapy rules.
Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.
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Colorado Proposition 122 / Natural Medicine Health Act (2022)
Decriminalized personal use of psilocybin, psilocyn, DMT, ibogaine, and mescaline (non-peyote) for adults 21+; authorized state-licensed Healing Centers for psilocybin-assisted therapy, with MDMA access permitted by state rule after June 2026. -
SB 23-290 Natural Medicine Regulation and Legalization
Implementing legislation establishing the Natural Medicine Division within DORA and the licensure framework for facilitators, healing centers, cultivators, and product manufacturers.
Colorado Healing Centers began licensing and operating in late 2024 and early 2025. The Colorado Department of Regulatory Agencies (DORA) Natural Medicine Division oversees facilitator licensure, healing center operations, testing, and track-and-trace. Federal law still classifies psilocybin as Schedule I, so DEA enforcement risk remains theoretical. The Colorado Medical Board regulates ketamine prescribing. Ryan Haight Act applies to telehealth ketamine.
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Nationwide
Psychedelic Therapy clinics across the US