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UpStream Root Cause Medicine
MD on staff OIG Cleared NPI Verified

UpStream Root Cause Medicine

8031 W Center Rd #221, Omaha, NE 68124, USA
5.0

About this clinic

UpStream Root Cause Medicine, a functional medicine and regenerative-medicine clinic in Omaha, specializes in peptide therapy, bioidentical hormone replacement therapy, and hormone optimization for patients seeking root-cause assessment rather than symptom management. The practice offers cell-based and orthobiologic treatments including platelet-rich plasma therapy, prolotherapy, and prolozone injections for musculoskeletal and joint conditions. IV nutrient therapy, ozone therapy, and hyperbaric oxygen therapy support systemic healing, while chelation therapy and clinical nutrition address metabolic and inflammatory foundations. Additional offerings include transcranial magnetic stimulation, neurofeedback, and laser-based modalities. Treatment plans are individualized following comprehensive functional-medicine evaluation, positioning the clinic as an integrative alternative for patients navigating hormone imbalance, chronic pain, and age-related decline.

Treatments offered

PRP Therapy

Emerging evidence

Colon Hydrotherapy

Insufficient evidence

Ozone Therapy

Experimental evidence

IV Therapy

Insufficient evidence

Transcranial Magnetic Stimulation (TMS)

Strong evidence

Neurofeedback Therapy

Emerging evidence

IV Hydration

Emerging evidence

Hyperbaric Oxygen Therapy (HBOT)

Strong evidence

Oxygen Therapy

Strong evidence

Arthritis Treatment

Strong evidence

Chelation Therapy

Strong evidence

Lyme Disease Treatment

Strong evidence

Peptide Therapy

Experimental evidence

Red Light Therapy

Emerging evidence

Hormone Replacement Therapy (HRT)

Strong evidence

Contact information

View on map
8031 W Center Rd #221, Omaha, NE 68124, USA
Website

Office hours

Monday – Friday
9am – 5pm
Saturday – Sunday
Closed

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Patient reviews

5.0

Based on 8 Google reviews

5 ★
4 ★
3 ★
2 ★
1 ★

Before joining UpStream, I experienced the care firsthand as a patient. Two days before an international trip, I developed a chest infection. Historically, that situation always required antibiotics for me. Instead, I received UBVI and a Vitamin C IV. The improvement was remarkable. I traveled to Europe for 10 days without illness and felt strong the entire time. That experience deeply impacted my perspective on integrative and supportive care.

Orna Hoban · February 11th, 2026

I came to this clinic in December of 2022 and I was in a desperate state. My health had suddenly fallen apart and I had no idea why, I was only in my late 20’s. I had been diagnosed with POTS but other than that my other doctors didn’t know what to do. When I found Dr. Ryan at UpStream, it literally changed my life. I found out I wasn’t crazy, I had long-covid. Dr. Ryan is one of the few people that actually knows a TON about Covid and long-covid and she was confident in treating it. I finally had my life back. This whole experience changed my life and got me in to more natural medicine, I have continued to be a patient even after healing from long-covid. Thank you UpStream!

Allison Weaver · May 13th, 2026

My husband and I have been coming here for a few years now. The staff is always very friendly and knowledgeable. We got results for some health concerns that we had using their protocols that we weren’t able to get help with at our general practitioner. We trust Dr Ryan and Tiffany more than our general practitioner.

Mike & Rhonda Leonard · May 12th, 2026

Treatments offered in Omaha, NE

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