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30 Best Ketamine Therapy Clinics in Denver, Colorado

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

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Denver, CO

Ketamine Therapy clinics in Denver

A ketamine treatment center in Denver can be a psychiatric office, an infusion suite, or a wellness clinic, and the first thing to confirm is the delivery method: an intramuscular injection goes into a muscle, while an intravenous infusion delivers medication through a vein. Denver ketamine therapy options include offices around Cherry Creek near Colorado Boulevard and offerings west in Lakewood, where muscle injections are available. Some centers describe themselves as serving the wider Denver metro, including Aurora and Boulder along US-36, so a search result can point to a suburban address. Confirm where each appointment happens, compare travel along Colorado Boulevard and I-25 with trips toward Lakewood, and arrange an adult escort home.

Expect injection treatment in a medical or psychiatric office, with licensed medical staff administering medication and monitoring recovery. People typically seek out a ketamine treatment center after standard care for depression, anxiety, PTSD, or certain chronic pain conditions has not helped enough, and a Denver clinic should ask why you are seeking this treatment rather than assume it fits every diagnosis. An initial consultation should review your diagnosis, previous treatments, medications, blood pressure, and substance use history. Ask who prescribes, who stays available during treatment, and what training the team has in managing breathing problems or severe distress. Confirm whether psychotherapy is included or arranged separately.

Before booking, request the medication's formulation and source, plus written information about side effects, risks, and discharge instructions. Ketamine is a legal prescription medication when administered by licensed clinicians, though using it for depression, anxiety, or other mental health conditions is off-label, meaning the FDA has not specifically approved that use. Ask how follow-up tracks symptoms, who handles concerns between visits, and when treatment would change if it does not help. A written quote should distinguish assessment, medication, monitoring, psychotherapy, and follow-up, with additional charges identified. Evidence about sustained benefit remains limited, and this is usually cash pay.

Regenerated.com does not sell organic listing order or paid ranking within it. Featured placements are labeled and limited in number, while Verified indicates credential checks rather than spending. The directory is free for patients, and inclusion does not endorse a provider or treatment.

The national ketamine therapy hub explains how the medication works and reviews the broader evidence. Use How to read a Regenerated city hub and Featured vs Verified vs organic to understand the directory's comparison tools and labels.

30 Clinics, showing page 2 of 2

Ryan Hicks Counseling & Psychotherapy
(33)
Physician status unknown

Ryan Hicks Counseling & Psychotherapy

Denver, CO

Ryan Hicks Counseling & Psychotherapy, based in Denver, offers Ketamine Therapy and Psychedelic Therapy as clinical protocols for patients pursuing mental-health treatment. The practice specializes i…

  • Ketamine Therapy
  • Psychedelic Therapy
ClearSpring Pharmacy
(178)
Physician status unknown

ClearSpring Pharmacy

Denver, CO

ClearSpring Pharmacy, a specialized pharmaceutical practice in Denver, offers customized medication formulation alongside clinical protocols for ketamine therapy, hormone replacement therapy, and tes…

  • Ketamine Therapy
  • Erectile Dysfunction (ED) Treatment
  • Hormone Replacement Therapy (HRT)
  • Testosterone Replacement Therapy (TRT)
Karen Wise Therapy
(37)
Physician status unknown

Karen Wise Therapy

Denver, CO

Karen Wise Therapy, a mental-health practice in Denver, offers ketamine-assisted psychotherapy alongside individual therapy and couples counseling. The practice specializes in treatment-resistant dep…

  • Ketamine Therapy
Sona Collective
(15)
Physician status unknown

Sona Collective

Denver, CO

Sona Collective, a ketamine and psychedelic-assisted therapy practice in Denver, specializes in trauma-informed somatic and mindfulness-based treatment for adults with treatment-resistant presentatio…

  • Ketamine Therapy
  • Psychedelic Therapy
Maggie Okoniewski
(6)
Physician status unknown

Maggie Okoniewski

Denver, CO

Maggie Okoniewski, a licensed clinical social worker and registered psychotherapist in Denver, provides individual therapy for adults and adolescents using a strength-based, holistic approach. The pr…

  • Ketamine Therapy
  • Psychedelic Therapy
Prime IV Hydration & Wellness - Cherry Creek
(113)
Physician status unknown

Prime IV Hydration & Wellness - Cherry Creek

Denver, CO

Prime IV Hydration & Wellness in Denver specializes in IV nutrient therapy, NAD+ infusions, and peptide protocols alongside bioidentical hormone replacement therapy and hormone-pellet implantation. T…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • IV Therapy
  • IV Hydration
  • Hyperbaric Oxygen Therapy (HBOT)
Rooted Mind Therapy
(4)
Physician status unknown

Rooted Mind Therapy

Denver, CO

Rooted Mind Therapy, a ketamine-assisted therapy clinic in Denver, offers Ketamine Therapy and Ketamine Assisted Psychotherapy (KAP) within an integrative, mindfulness-based somatic framework. The pr…

  • Ketamine Therapy
Heart Wild Therapy
(10)
Physician status unknown

Heart Wild Therapy

Denver, CO

Heart Wild Therapy, a ketamine-assisted therapy clinic in Denver, specializes in ketamine therapy for treatment-resistant depression, anxiety, PTSD, and related mental-health conditions. The practice…

  • Ketamine Therapy
Interventional Health Sciences
(160)
Physician status unknown

Interventional Health Sciences

Denver, CO

Interventional Health Sciences, a regenerative-medicine clinic in Denver, specializes in platelet-rich plasma therapy and regenerative-medicine protocols for musculoskeletal and chronic-pain conditio…

  • PRP Therapy
  • Ketamine Therapy
  • Arthritis Treatment
  • Migraine Treatment
Denver Wellness Associates
(886)
Physician reported in record

Denver Wellness Associates

Denver, CO

Denver Wellness Associates, a mental health clinic in Denver, specializes in ketamine therapy and transcranial magnetic stimulation (TMS) for treatment-resistant depression, anxiety, and related cond…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Psychedelic Therapy
Shift Healing
(3)
Physician status unknown

Shift Healing

Denver, CO

Shift Health Psychology, in Wheat Ridge, specializes in ketamine-assisted psychotherapy for patients addressing trauma, depression, anxiety, and related psychological conditions. The clinic combines …

  • Ketamine Therapy
  • Psychedelic Therapy
Psyche
(72)
Physician status unknown

Psyche

Denver, CO

Psyche, a ketamine-therapy clinic in Denver, specializes in ketamine infusions and esketamine (Spravato) for treatment-resistant depression and related conditions. The clinic offers both traditional …

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
Psychedelic Somatic Institute
(9)
Physician status unknown

Psychedelic Somatic Institute

Denver, CO

Psychedelic Somatic Institute in Denver offers ketamine-assisted psychotherapy alongside functional-medicine evaluation and hormone-replacement therapy for patients with treatment-resistant depressio…

  • Ketamine Therapy
  • Psychedelic Therapy
  • Hormone Replacement Therapy (HRT)
Attuned Holistic Healing
(4)
Physician status unknown

Attuned Holistic Healing

Denver, CO

Attuned Holistic Healing, a ketamine therapy clinic in Denver, offers Ketamine Therapy alongside trauma-informed psychotherapy for patients managing treatment-resistant depression, anxiety, PTSD, and…

  • Ketamine Therapy
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Regulatory context

A note on Colorado's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • Colorado Proposition 122 / Natural Medicine Health Act (2022)
    Decriminalized personal use of psilocybin, psilocyn, DMT, ibogaine, and mescaline (non-peyote) for adults 21+; authorized state-licensed Healing Centers for psilocybin-assisted therapy, with MDMA access permitted by state rule after June 2026.
  • SB 23-290 Natural Medicine Regulation and Legalization
    Implementing legislation establishing the Natural Medicine Division within DORA and the licensure framework for facilitators, healing centers, cultivators, and product manufacturers.

Colorado Healing Centers began licensing and operating in late 2024 and early 2025. The Colorado Department of Regulatory Agencies (DORA) Natural Medicine Division oversees facilitator licensure, healing center operations, testing, and track-and-trace. Federal law still classifies psilocybin as Schedule I, so DEA enforcement risk remains theoretical. The Colorado Medical Board regulates ketamine prescribing. Ryan Haight Act applies to telehealth ketamine.

Ketamine Therapy in Denver, answered.

An intramuscular injection delivers ketamine into a muscle; an IV infusion delivers it gradually through a vein. Denver-area providers may offer one route without the other, so confirm the method before scheduling. An infusion can be adjusted or stopped during delivery, while an injected dose cannot be withdrawn. Both require screening, monitoring, and recovery arrangements. Nasal esketamine is a separate treatment with different eligibility and administration requirements.

Ketamine injections and infusions for depression are commonly cash pay, although coverage depends on the service and insurance plan. Assessment, psychotherapy, or nasal esketamine may have different benefits. Request an itemized quote covering medication, administration, monitoring, therapy, testing, and follow-up, then confirm coverage with your insurer. This Denver page does not publish averages because delivery methods, staffing, and included services differ enough to make a single figure misleading.

Adults whose depression has not improved adequately with standard care may be considered after a medical and psychiatric assessment. Uncontrolled blood pressure, unstable heart disease, active psychotic symptoms, or pregnancy may mean postponing treatment or choosing another approach. Some programs also explore ketamine for bipolar depression or alongside addiction treatment, but eligibility and protocols for those uses differ from standard depression care, so ask how your diagnosis is addressed. A Denver clinician should explain the reason for recommending ketamine and coordinate with whoever manages your ongoing mental health care.

Research supports short-term symptom improvement for some adults with treatment-resistant depression, particularly with IV ketamine. Response varies, and improvement may fade. Evidence for muscle injections is less developed than for IV treatment, and questions remain about maintenance treatment and long-term harms. Ketamine itself is not FDA approved for psychiatric conditions; nasal esketamine has specific depression indications. Ask how the evidence applies to your diagnosis and proposed delivery method.

Care should begin with assessment, informed consent, and agreed goals, followed by monitored treatment and recovery before discharge. Dosing and session counts, including whether a lower microdose approach is used, are set after assessment and vary by clinic, which is why this page does not publish fixed schedules. Many offices use a quiet room with dimmed lighting or music for comfort. Ask whether psychotherapy and follow-up happen at the same Denver-area office, arrange an adult escort, and obtain a contact for concerns between appointments.

Possible effects include nausea, dizziness, sleepiness, increased blood pressure, and dissociation, a feeling of being detached from yourself or your surroundings. Breathing problems and intense psychological distress can occur, and repeated exposure raises concerns about bladder symptoms and misuse. Ask how staff monitor you, respond to complications, and decide when you can leave. Written instructions should explain which symptoms need urgent medical attention after discharge.

Get the names and professional roles of the prescriber, administering clinician, and any therapist. Use Colorado's Department of Regulatory Agencies license lookup to check current status and available disciplinary records. Ask about psychiatric assessment, monitoring, and emergency response training. Unlike a general web search, this page groups Denver-area options for comparison; the national hub covers mechanisms and evidence. Neither a listing nor a license check establishes suitability for your needs.

Featured identifies a labeled promotional placement, and those spaces are capped. Verified means credentials have been checked, not that a provider has paid more or will achieve a particular result. Organic order is not sold. Compare delivery method, clinical supervision, follow-up, and the actual treatment address alongside these labels. Regenerated.com is free for patients, and directory inclusion is not an endorsement of a clinician or treatment.

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