12 Best Ketamine Therapy Clinics in Portland, Oregon (2026)

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This page lists directory records associated with Ketamine Therapy in the Portland, Oregon browsing area. A browsing area can include nearby municipalities. Confirm each clinic's street address and current services directly.

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12. Source: the current directory result set, including pages beyond this screen.

Treatment filter:

Ketamine Therapy.

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Listing information is not an independent clinic evaluation. Record updates do not establish field-level check dates.

Read the Ketamine Therapy guide for the educational context behind this treatment category.

Ketamine Therapy clinics in Portland

Patients searching for ketamine therapy in Portland, Oregon will notice that providers cluster in a few areas rather than spreading evenly across the metro. The strongest concentration sits near the Pearl District and Northwest Portland, within reach of the medical offices on and around Pill Hill by OHSU and Legacy Good Samaritan. A second group of practices sits along the US 26 corridor toward Beaverton and Hillsboro, convenient for patients from Washington County. Southeast Portland and the Lloyd District have fewer options, and residents there often travel north or west to reach a monitored infusion suite. Confirm the exact address and whether the office is a staffed medical setting before you book.

In the Portland area, ketamine therapy for depression is usually delivered as an intravenous infusion or a nasal esketamine session inside a monitored office, with a clinician and support staff tracking vital signs through the session and the recovery period afterward. A first appointment typically covers a psychiatric and medical history, a medication review, and a conversation about treatment goals. If you plan to use flexible spending or health savings account funds, ask whether the evaluation, medication, and monitoring qualify, and what documentation they can provide; eligibility depends on your plan, not on anything this page can confirm. Follow up is based on how you respond, not on a number of visits decided in advance.

Before choosing a Portland provider, ask who prescribes and administers the ketamine, who stays in the room, and where the medication is sourced. Ask how side effects and risks are disclosed in writing, what happens if the treatment does not help, and request a quote that itemizes the evaluation, the medication, the monitoring, and any follow up visits, so costs are clear before you commit.

The order clinics appear in on this page is not something a provider pays for, and the organic listing is never for sale. Featured placements are labeled and capped in number, and a Verified label means a clinic's credentials have been checked, not that it spent more to appear. Regenerated.com is free for patients to use, and being listed here is not an endorsement of any clinic.

For the national mechanism and evidence behind the treatment, see the ketamine therapy hub. For more on how to read this list, see How to read a Regenerated city hub and Featured vs Verified vs organic.

A note on Oregon's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

Oregon Measure 109 / Psilocybin Services Act (2020, operational January 2023)
Established the nation's first regulated psilocybin therapy framework, with state-licensed Service Centers, Facilitators, manufacturers, and testing laboratories overseen by the Oregon Health Authority Psilocybin Services Section.
Measure 110 / Drug Addiction Treatment and Recovery Act (2020, partially repealed 2024)
Decriminalized personal possession of small amounts of all drugs including psilocybin and MDMA; partially repealed in 2024 re-criminalizing possession as a misdemeanor.
Oregon Uniform Controlled Substances Act
Mirrors federal scheduling outside the Psilocybin Services framework.

Oregon Psilocybin Services centers have been operational since 2023, with facilitators and service centers licensed statewide. The Oregon Health Authority Psilocybin Services Section oversees licensure, product testing, facilitator training, and facility standards. Federal psilocybin Schedule I status remains unchanged, but DEA has not brought enforcement actions against Measure 109-compliant operations to date. The Oregon Medical Board regulates ketamine prescribing.

Ketamine Therapy in Portland, answered.

Ketamine therapy uses a dissociative anesthetic, given at doses far lower than those used in surgery, to relieve depression that has not responded to standard treatment. In Portland, it is generally given as an intravenous infusion or a nasal esketamine session inside a monitored medical office, with staff present throughout. It is typically used alongside, not instead of, ongoing psychiatric care, and coordination with your existing treatment team varies by provider.

Cost depends on whether you receive IV ketamine, nasal esketamine, or ketamine paired with psychotherapy, and on how a practice structures its visits. Most IV ketamine for depression is billed as cash pay, while esketamine and psychiatric visits may be covered depending on your plan. FSA and HSA eligibility depends on your specific plan, so ask any Portland office for an itemized quote and the documentation they provide for reimbursement.

Reported effects can include dissociation, dizziness, nausea, changes in blood pressure, and short term confusion, which is why sessions take place in a monitored setting with staff tracking vital signs and mental status throughout and afterward. A Portland provider should explain these risks in writing before treatment begins and describe what happens if you have a reaction during a session, rather than leaving it to be discovered on the day.

Candidates are typically adults with depression or related conditions that have not improved with standard medication or therapy, following a psychiatric and medical evaluation. People with certain uncontrolled cardiovascular conditions, some psychotic disorders, or active substance misuse are often told to wait or are referred elsewhere until those issues are addressed. A Portland provider should explain this screening clearly rather than scheduling treatment before it is complete.

Intravenous ketamine is delivered through an IV line at a clinician-set rate over the course of a session, while esketamine is a nasal spray formulation with its own dosing schedule and monitoring requirements. Doses in either case are set by the prescribing clinician based on your history, response, and how you tolerate treatment, not by a fixed formula, which is why this page does not publish dosing figures.

Look for a licensed physician, nurse practitioner, or psychiatric prescriber who personally evaluates you and either administers or directly supervises the session, along with staff trained to respond to a medical reaction. You can verify an Oregon medical or nursing license through the Oregon Medical Board or the Oregon State Board of Nursing before you book, rather than relying on a clinic's own description of its staff.

Research on ketamine for bipolar depression and for substance use disorders is active but still developing, and it is not established as a first line treatment for either. Some clinicians use it off label as part of a broader care plan, usually alongside other psychiatric treatment rather than on its own. Ask a Portland provider directly what their evidence base is for your specific diagnosis before assuming it is a standard option.

A general search mixes advertising, directories, and individual clinic marketing with little way to tell them apart. On this page, organic order is not sold, Featured slots are labeled and limited in number, and Verified means a clinic's credentials have been checked rather than reflecting ad spend. Regenerated.com is free for patients, and inclusion in this directory does not amount to an endorsement of any listed clinic.

12 Best Ketamine Therapy Clinics in Portland, Oregon

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

What does this directory page list?

Ketamine Therapy clinics in Portland

12 Clinics

Portland Ketamine Clinic

Synaptic Institute

Active Path Mental Health

Alive IV and Wellness

Empathy Grove Ketamine Therapy & Wellness Center

The Ren Clinic

Greenbrook Mental Wellness Centers

Peter H Addy

Depression Treatment Clinic Portland- BestMind Behavioral

Atomic MindWorks

Evolve Health TMS and Spravato

Áureo

A note on Oregon's ketamine therapy rules.

Ketamine Therapy in Portland, answered.

Ketamine Therapy in nearby Cities

Other Treatments available in Portland

12 Best Ketamine Therapy Clinics in Portland, Oregon

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

What does this directory page list?

Ketamine Therapy clinics in Portland

12 Clinics

A note on Oregon's ketamine therapy rules.

Ketamine Therapy in Portland, answered.

What is ketamine therapy and how is it used to treat depression in Portland?

How much does ketamine therapy cost in Portland, and can I use FSA or HSA funds or insurance to help pay for it?

What are the side effects of ketamine therapy, and how are they monitored during a session?

Who is generally considered a good candidate for ketamine therapy in Portland, and who is usually told to wait or look elsewhere?

What is the difference between intravenous ketamine infusion therapy and nasal esketamine, and how are doses decided?

What credentials and supervision should I look for in a Portland ketamine provider, and how do I check a license in Oregon?

Can ketamine therapy help with bipolar disorder or addiction, and what does the current evidence support?

How does this Portland listing differ from a general web search, and how do Featured, Verified, and organic order work here?

Ketamine Therapy in nearby Cities

Other Treatments available in Portland