Ketamine infusions, psilocybin, MDMA-assisted therapy, and psychedelic medicine
An evidence-based overview of psychedelic-assisted therapy, covering psilocybin, MDMA, ketamine, and other substances being studied for PTSD, depression, addiction, and more.
Ketamine blocks NMDA receptors involved in central sensitization, making it one of the few treatments that can interrupt the self-reinforcing cycle of chronic pain. Here is what the evidence shows.
Spravato (esketamine nasal spray) and IV ketamine infusions both target treatment-resistant depression through NMDA receptor blockade, but they differ in pharmacology, cost, insurance coverage, and clinical evidence.
A complete guide to ketamine therapy: the science behind it, conditions it treats, IV vs nasal spray vs oral forms, costs, risks, what a session looks like, and how to find a provider.
Medicare and Medicaid Coverage Medicare Part B generally covers Spravato, though copay amounts vary by plan. The Janssen copay assistance program is not available to Medicare, Medicaid, or government-insured patients due to federal anti-kickback regulations. However, some Spravato clinics work with patients to find other financial assistance options, and some state Medicaid programs have begun…
A detailed price breakdown of ketamine therapy by type: IV infusions ($400-800/session), Spravato nasal spray (often insurance-covered), oral/sublingual ($200-400/month), and IM injections. Covers insurance, HSA/FSA options, financing, and tips for finding affordable treatment.
At a Glance Ketamine works differently than traditional anxiety medications by modulating glutamate and NMDA receptors rather than serotonin or GABA. Clinical evidence shows rapid and significant anxiety reduction, often within hours to days rather than weeks. Multiple administration routes are available: IV infusion, intramuscular injection, nasal spray (Spravato), sublingual, and oral lozenges. Most patients…
How ketamine treats chronic pain through NMDA antagonism and central sensitization reversal. Evidence for CRPS (50-80% response), fibromyalgia, neuropathic pain, infusion protocols, and at-home options.
Ketamine therapy is one of the fastest-acting treatments for treatment-resistant depression, chronic pain, and PTSD. This guide covers the science, different formats (IV, nasal, oral, IM), costs, and what a session actually looks like.
How ketamine therapy works for PTSD through NMDA blockade, fear extinction, and neuroplasticity. Research evidence, treatment protocols, what to expect, and limitations.