NAD+, senolytics, telomere therapy, and science-backed longevity interventions
Rapamycin (sirolimus) is the only drug shown to reliably extend lifespan in animals, but human longevity evidence is still early and unproven. Here is what the science shows in 2026, plus the real risks.
Klotho is a protein and hormone that helps regulate phosphate and vitamin D and is a leading longevity research target. Here is what the science actually shows, and what it does not.
Senolytics target the zombie senescent cells that drive aging and inflammation. Strong in mice, early in humans. Here is what the evidence actually shows.
Therapeutic plasma exchange (plasmapheresis) is proven first-line care for autoimmune and neurological diseases. Its anti-aging use is experimental. Here is what the evidence shows.
An honest 2026 evidence review of methylene blue: what it is, how it works in mitochondria, the brain-fog and mood claims, serotonin syndrome and G6PD risks, dosing, and an honest evidence grade.
Dasatinib plus quercetin (D+Q) was the first senolytic combination shown to clear senescent cells. Here is what it is, what the Mayo Clinic research and small human pilot trials found, and why dasatinib is prescription chemotherapy that is not safe to self-experiment with.
Fisetin is a flavonoid in strawberries and apples that clears senescent cells and extends lifespan in aged mice. Here is what the human evidence, dosing debates, and safety picture actually show.
An honest evidence review of urolithin A, the gut-microbiome mitophagy activator. What the randomized human trials show for muscle strength and mitochondrial health, the 500 to 1,000 mg doses used, safety, and what remains unproven.
Review the evidence behind popular anti-aging supplements including NMN, resveratrol, CoQ10, collagen, spermidine, fisetin, and more.
At a Glance NAD+ levels decline substantially with age – this decline is now considered a hallmark of the aging process. The mechanism is well-established: NAD+ fuels sirtuins, PARPs, and CD38 – enzymes critical for DNA repair, mitochondrial function, and cellular maintenance. Animal data is strong: NAD+ repletion has extended healthspan and reversed age-related decline…