How much does ketamine therapy cost in San Francisco?

In San Francisco, a single IV ketamine infusion typically runs 600 to 1,000 dollars, with a full 6 session induction protocol at 3,600 to 6,000. Premium clinics on the higher end, more affordable providers on the lower end. Intramuscular ketamine often costs less, around 250 to 500 per session. Compounded ketamine lozenges via telehealth run 250 to 500 per month. Spravato (esketamine) is frequently covered by insurance for treatment resistant depression; out of pocket list price is roughly 600 to 900 per treatment session, with most patients paying a copay.

Is ketamine FDA approved?

Ketamine is a Schedule III controlled substance and has been FDA approved as an anesthetic since 1970. Spravato (esketamine), a derivative nasal spray, is FDA approved for treatment resistant depression under a REMS program requiring in clinic administration and post dose monitoring. IV, intramuscular, and compounded oral ketamine for depression, PTSD, and chronic pain are used off label with Emerging to Strong evidence depending on indication. Off label prescribing is legal for DEA registered providers but must follow state and federal controlled substance rules.

Who provides ketamine therapy in San Francisco?

San Francisco ketamine is delivered by MDs and DOs (typically psychiatrists, anesthesiologists, emergency medicine, or pain specialists) holding a DEA registration and California controlled substance authority. Nurse practitioners and physician assistants may prescribe or administer depending on California scope of practice and supervisory rules. Spravato requires a REMS certified clinic and certified prescriber. Verify the provider's DEA registration, board certification, and whether a monitoring clinician is present during infusions.

Are there telehealth options for ketamine in California?

Yes, with caveats. Mindbloom, Joyous, Innerwell, and similar platforms prescribe compounded ketamine lozenges to California residents through telehealth, subject to the Ryan Haight Act and DEA special registration rules currently in effect. These programs pair at home dosing with virtual integration support and cost roughly 250 to 500 per month. In clinic IV and intramuscular ketamine remain the standard for treatment resistant depression and PTSD and cannot be delivered via telehealth. Spravato always requires in clinic REMS administration.

How do I choose a reputable ketamine clinic in San Francisco?

Verify DEA registration on the DEA Office of Diversion Control registrant lookup and California medical board license status. Confirm board certification in psychiatry, anesthesiology, emergency medicine, or pain medicine. Ask about the monitoring protocol during infusion (vitals, continuous clinician presence), integration therapy options, and the clinic's crisis and safety plan. Check whether the clinic is Spravato REMS certified if that is your treatment path. Be cautious of providers who skip screening, push large prepaid packages, or offer take home IV ketamine.

14 Best Ketamine Therapy Clinics in San Francisco, California

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

SB 803 (2023, vetoed) and SB 1012 (2024, stalled)
Proposed regulated therapeutic access to psilocybin, MDMA, mescaline, and DMT; Governor Newsom vetoed SB 58 (2023) citing lack of treatment guidelines.
Local decriminalization resolutions
Oakland (2019), Santa Cruz (2020), Arcata, San Francisco, and Berkeley have passed non-binding resolutions deprioritizing enforcement of natural psychedelics; no legal therapeutic framework.

California enforces federal DEA scheduling. The Medical Board of California investigates prescriber misconduct, including ketamine diversion and inadequate patient monitoring. Several high-profile California ketamine-related deaths (including Matthew Perry's 2023 overdose) have intensified board scrutiny of clinic practices. DEA enforcement targets compounding, diversion, and Ryan Haight Act telehealth compliance.

14 Best Ketamine Therapy Clinics in San Francisco, California

Every listing is checked against federal records, reviewed for evidence, and confirmed still operating. No pay-to-play. No guesswork.

Ketamine Therapy clinics in San Francisco

Polaris Insight Center, Ketamine Assisted Psychotherapy

Infinite Health Zone Integrative Medicine

Elemental Wisdom

Integral Counseling and Psychotherapy

San Francisco Therapy and Integration

Healthwell Physical Therapy Group

Vital Total Health Medical Group

Drip Refresh Mobile IV Therapy

Quantum Integral Healing Arts

Clarus Health

The Holistic Counseling Center

CBT Therapy

Avid Sports Medicine

Clarus Medical Aesthetics

A note on California's ketamine therapy rules.

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