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218 Best Ketamine Therapy Clinics in California

Compare clinic listings by treatment and location. A listing is not a medical endorsement. Organic rank is never for sale; Featured placements are labeled and separate from organic results.

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Read the Ketamine Therapy guide: evidence, costs and questions to ask

California

Ketamine Therapy clinics in California

Searching for a ketamine clinic in California turns up supply concentrated in a few metro regions rather than spread evenly across the state. The Los Angeles area and the greater Bay Area carry most of California's ketamine therapy capacity, with San Diego and Sacramento adding further options. The Central Valley, the far north, and much of the Inland Empire have comparatively little, so someone outside these population centers should expect to travel, sometimes considerably, to reach an established provider.

California has no ketamine-specific licensing statute beyond the general rules already governing controlled substances. A physician or a supervised physician assistant typically orders and oversees treatment, and a registered nurse or nurse practitioner may administer it as part of that medical team. Treatment is usually delivered in a physician's office or a dedicated infusion suite with monitoring equipment, rather than a purely wellness setting, though wellness-branded locations do exist. Scope of practice for nurse practitioners varies with their supervision agreement, so confirm who is actually present during your session.

To verify a provider, check physicians and physician assistants through the Medical Board of California or, for osteopathic physicians, the Osteopathic Medical Board of California. Check nurses and nurse practitioners through the California Board of Registered Nursing. A clean license record shows someone is permitted to practice; it does not establish ketamine-specific experience or predict how you will respond to treatment.

Before booking, ask who evaluates you, who is present and supervising during the infusion, what is being administered and where it is sourced, and how risks are disclosed in writing. Ask what happens if treatment does not help, and request an itemized quote covering evaluation, medication, monitoring, and any included therapy or follow-up.

This listing's order is not for sale. Featured slots are labeled and limited in number, Verified means a clinic has completed credential checks rather than paid for placement, and browsing Regenerated.com costs patients nothing. Appearing in this directory is not an endorsement of any listed clinic.

The national ketamine therapy hub covers the mechanism and the evidence behind IV ketamine and nasal esketamine in more depth. For more on how to read a listing like this one, see How to read a Regenerated city hub and Featured vs Verified vs organic.

218 Clinics, showing page 11 of 15

Kloud Health
(64)
Physician reported in record

Kloud Health

West Hollywood, CA

Kloud Health, an IV therapy clinic in Los Angeles, offers intravenous nutrient protocols alongside ketamine infusion therapy for treatment-resistant depression and anxiety. The practice combines IV H…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • PRP Therapy
  • IV Therapy
  • IV Hydration
Optimal Medical Group
(231)
Physician reported in record

Optimal Medical Group

Fresno, CA

Optimal Medical Group, a regenerative medicine clinic in Fresno, specializes in hormone replacement therapy and peptide therapy alongside cell-based treatments including exosome protocols. The practi…

  • Shockwave Therapy
  • IV Therapy
  • Acne Treatment
  • Ketamine Therapy
  • Peptide Therapy
Mental Health & Medication Assisted, Center
(12)
Physician reported in record

Mental Health & Medication Assisted, Center

Los Angeles, CA

Mental Health & Medication Assisted Center, a ketamine-therapy clinic in Los Angeles, offers ketamine infusion treatment for treatment-resistant depression, anxiety, and PTSD. The practice serves ado…

  • Ketamine Therapy
California Pain Medicine Center
Physician reported in record

California Pain Medicine Center

Santa Monica, CA

California Pain Medicine Center, located in Santa Monica, offers ketamine infusion therapy and platelet-rich plasma injections alongside conventional pain-management procedures for patients with acut…

  • PRP Therapy
  • Biofeedback Therapy
  • Ketamine Therapy
  • Arthritis Treatment
San Jose Integrative Wellness Center
Physician status unknown

San Jose Integrative Wellness Center

Los Gatos, CA

San Jose Integrative Wellness Center in Los Gatos offers a comprehensive regenerative-medicine and integrative-psychiatry practice. The clinic specializes in Transcranial Magnetic Stimulation (TMS) a…

  • NAD IV Therapy
  • Vitamin IV Therapy
  • Ozone Therapy
  • Transcranial Magnetic Stimulation (TMS)
  • Hyperbaric Oxygen Therapy (HBOT)
Relucent Psychology Group
(17)
Physician status unknown

Relucent Psychology Group

San Jose, CA

Relucent Psychology Group, a ketamine-therapy clinic in San Jose, offers ketamine-assisted psychotherapy alongside diagnostic evaluation for patients with treatment-resistant depression, anxiety, and…

  • Ketamine Therapy
Los Angeles TMS Institute
(1)
Physician reported in record

Los Angeles TMS Institute

West Los Angeles, CA

Los Angeles TMS Institute, a neuromodulation clinic in Los Angeles, specializes in transcranial magnetic stimulation (TMS) and ketamine therapy for treatment-resistant depression and mood disorders. …

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
Renew Ketamine Infusion
(30)
Physician status unknown

Renew Ketamine Infusion

Mission Viejo, CA

Renew Ketamine Infusion, located in San Juan Capistrano, California, specializes in ketamine therapy for treatment-resistant depression, anxiety, PTSD, and chronic pain conditions. The clinic offers …

  • Ketamine Therapy
  • Migraine Treatment
Psychiatry Treatment Centers
(107)
Physician reported in record

Psychiatry Treatment Centers

Los Angeles, CA

Psychiatry Treatment Centers, based in Los Angeles, offers ketamine therapy and esketamine (Spravato) treatment for treatment-resistant depression and related conditions, alongside Transcranial Magne…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
  • Psychedelic Therapy
Blair Wellness Group
(20)
Physician status unknown

Blair Wellness Group

Irvine, CA

Blair Wellness Group, a ketamine-therapy clinic in Irvine, California, offers ketamine-assisted psychotherapy alongside hormone replacement therapy and platelet-rich fibrin treatment. The practice fo…

  • PRP Therapy
  • Ketamine Therapy
  • Arthritis Treatment
  • Hormone Replacement Therapy (HRT)
Salma Health (formerly Kaizen Brain Center)
(85)
Physician reported in record

Salma Health (formerly Kaizen Brain Center)

La Jolla, CA

Salma Health, a neuromodulation clinic in La Jolla, specializes in Transcranial Magnetic Stimulation (TMS) for treatment-resistant depression, anxiety, PTSD, and obsessive-compulsive disorder. TMS us…

  • Transcranial Magnetic Stimulation (TMS)
  • Ketamine Therapy
The Holistic Counseling Center
(1)
Physician reported in record

The Holistic Counseling Center

San Francisco, CA

The Holistic Counseling Center, operating in San Francisco and multiple Northern California locations, provides ketamine therapy alongside integrative mental-health counseling. The practice specializ…

  • Ketamine Therapy
Better U
(61)
Physician reported in record

Better U

Los Angeles, CA

Better U, a ketamine-therapy clinic in Los Angeles, specializes in esketamine and ketamine treatment for treatment-resistant depression, anxiety, and PTSD. The clinic offers at-home ketamine protocol…

  • Ketamine Therapy
  • Psychedelic Therapy
  • Erectile Dysfunction (ED) Treatment
  • Hormone Replacement Therapy (HRT)
  • NAD IV Therapy
Home-LA Psychiatry & Ketamine Therapy
(11)
Physician status unknown

Home-LA Psychiatry & Ketamine Therapy

Santa Monica, CA

Home-LA Psychiatry & Ketamine Therapy, based in Santa Monica, specializes in ketamine-assisted therapy for treatment-resistant depression, anxiety, and PTSD. The clinic combines ketamine protocols wi…

  • PRP Therapy
  • Ketamine Therapy
  • Arthritis Treatment
Enamory
(19)
Physician status unknown

Enamory

San Diego, CA

Enamory, a ketamine-assisted therapy clinic in San Diego, specializes in relationship-focused mental health care for couples, individuals, and groups. The practice offers ketamine therapy within a st…

  • Ketamine Therapy
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Regulatory context

A note on California's ketamine therapy rules.

Ketamine is a DEA Schedule III controlled substance, FDA-approved as a dissociative anesthetic and used off-label for treatment-resistant depression, PTSD, and chronic pain. The FDA approved esketamine (Spravato) in 2019 for treatment-resistant depression under a Risk Evaluation and Mitigation Strategy (REMS) program that requires in-office administration at certified sites. MDMA-assisted therapy remains Schedule I; the FDA issued a Complete Response Letter in August 2024 to Lykos Therapeutics on its MDMA new drug application. Psilocybin is Schedule I and holds FDA Breakthrough Therapy designation through sponsors such as Compass Pathways and Usona, but has not received FDA approval. Oregon Measure 109 (passed 2020, operational 2023) created a state psilocybin service center framework, and Colorado Proposition 122 (2022) authorized regulated healing centers.

  • SB 803 (2023, vetoed) and SB 1012 (2024, stalled)
    Proposed regulated therapeutic access to psilocybin, MDMA, mescaline, and DMT; Governor Newsom vetoed SB 58 (2023) citing lack of treatment guidelines.
  • Local decriminalization resolutions
    Oakland (2019), Santa Cruz (2020), Arcata, San Francisco, and Berkeley have passed non-binding resolutions deprioritizing enforcement of natural psychedelics; no legal therapeutic framework.

California enforces federal DEA scheduling. The Medical Board of California investigates prescriber misconduct, including ketamine diversion and inadequate patient monitoring. Several high-profile California ketamine-related deaths (including Matthew Perry's 2023 overdose) have intensified board scrutiny of clinic practices. DEA enforcement targets compounding, diversion, and Ryan Haight Act telehealth compliance.

Ketamine Therapy in , answered.

Most ketamine therapy clinics in California cluster around Los Angeles and the greater Bay Area, with additional options in San Diego and Sacramento. Coverage thins out considerably in the Central Valley, the far north, and many inland counties. If you live outside a major metro, call ahead about evaluation requirements, session length, and recovery arrangements, since you may need to plan a longer trip and a ride home than you would closer to one of these hubs.

Ketamine therapy generally refers to administering ketamine, by IV infusion, intramuscular injection, or as nasal esketamine, at sub-anesthetic doses to treat depression and, less commonly, other conditions. It appears to act on different brain pathways than standard antidepressants, which is why it is sometimes considered when other treatments have not helped. The formulation, dosing schedule, and whether psychotherapy is included vary by provider, so ask what is actually planned for you.

Short-term effects can include dissociation, elevated blood pressure, nausea, and disorientation during and shortly after a session, which is why monitored recovery time and a driver are standard parts of care. Risk is generally managed through screening, dosing, and supervision rather than eliminated. Ask your provider how they monitor vital signs during treatment, who is present, and what their plan is if you have an unexpected reaction.

Candidacy depends on diagnosis, treatment history, and medical factors such as cardiovascular health, substance use history, and certain psychiatric conditions that a prescriber needs to screen for directly. People with uncontrolled high blood pressure, certain heart conditions, or active psychosis are often told to wait or pursue other options. A thorough evaluation, not a general statewide rule, is what actually determines whether ketamine therapy is appropriate for you.

Ketamine itself is a controlled substance, and licensed physicians and physician assistants working under physician supervision may prescribe and oversee its use, with nurses or nurse practitioners often administering it as part of that team. California does not add a ketamine-specific rule on top of these general professional and controlled-substance requirements. Confirm who is supervising your specific treatment rather than assuming any one setting automatically meets this standard.

Physicians and physician assistants can be checked through the Medical Board of California or the Osteopathic Medical Board of California, and nurses or nurse practitioners through the California Board of Registered Nursing. These lookups confirm license status and show public disciplinary history. They will not tell you how experienced someone is with ketamine specifically, so pair that check with direct questions about training and supervision.

Coverage depends heavily on the formulation: IV ketamine for depression is commonly billed as cash pay, while nasal esketamine may be covered when a plan's specific criteria are met. Ask your insurer directly about authorization and network status, and ask any clinic for an itemized quote covering evaluation, medication, monitoring, and follow-up. This page does not publish average costs because arrangements vary too widely across providers to represent fairly.

This page covers supply and rules across the whole state rather than one metro's neighborhoods, while a city page addresses local geography in more detail and the national hub covers the treatment's mechanism and evidence generally. Unlike an open web search, listing order here is not sold, Featured placement is labeled and capped, and Verified reflects credential checks rather than advertising spend.

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