16 Best Ketamine Therapy Clinics in San Diego, California

Patients searching for ketamine depression treatment in San Diego will find clinics clustered along a few corridors, most pairing ketamine with ongoing psychiatric care rather than a one-time service, and most requiring a psychiatric intake screening before a first infusion. The UTC and La Jolla medical corridor near UC San Diego and Scripps holds a concentration of practices along I-5 and Genesee Avenue, with another cluster in Hillcrest along the 163. Farther north, practices along El Camino Real and I-5 through Carmel Valley, Encinitas, and Carlsbad serve North County, so patients in Oceanside or Vista rarely need to drive into the city center.

Locally, ketamine therapy is usually delivered as an intravenous infusion, sometimes as an intramuscular injection, inside a physician's office or dedicated infusion suite. A clinician, often an anesthesiologist, psychiatrist, or nurse practitioner, stays present to monitor vital signs and response throughout the session. A first visit typically covers a psychiatric and medical history review and a plain explanation of what the session will feel like, with follow-up built around ongoing care rather than a fixed number of sessions promised up front. For depression, that usually means coordination with the psychiatrist or therapist already treating the patient, since ketamine supports rather than replaces that care. Ketamine itself is FDA approved only as an anesthetic, so prescribing it for depression is off label, while a related nasal spray carries separate FDA approval for treatment-resistant depression.

Before booking, ask about the supervising clinician's credentials, whether a physician is present during the infusion, what is being administered, how risks are disclosed in writing, and what costs are included in a quoted price.

Listing order on the clinics below is not a paid ranking: organic position reflects profile completeness and relevance, not what a clinic pays Regenerated.com. Featured placements are labeled and capped at a small number of slots, and a Verified badge means a clinic's credentials have been checked, not that it spent more to appear higher. Regenerated.com is free for patients to use, and a listing here is not an endorsement of any clinic's outcomes. For how ketamine works, see the national ketamine therapy hub, and for more on reading this list, see How to read a Regenerated city hub and Featured vs Verified vs organic.